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22 Cards in this Set
- Front
- Back
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Where does the blood supply for the tubules come from? so what?
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the EFFERENT arterioles
So if there is a glomerular disease it will usually screw with the tubules too |
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Where does the blood for the medulla come from?
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Efferents too...same principle applies
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Who holds the glomerular capillaries together?
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Mesangial cells and matrix
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Who are the barriers to filtration?
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1: fenestrated capillary endothelium
2: Neg charge BM 3: Podocytes w/ slit diaphragm |
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Components of the Podocytes?
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Nephrin
Actin Filaments Podocin |
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Main component of the BM?
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Collagen Type IV
also laminin, HSPG, and Entactin |
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Make-up of Type IV Collagen?
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6 chains that each can get mutated and screw it all up
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Who makes Renin?
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Juxtaglomerular Cells
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What are three things that can happen to the Interstitium?
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Edema
Inflammation Fibrosis |
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Who are the Glomerular Syndromes?
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Acute Nephritic
Rapidly Progressive GN Nephrotic Asymptomatic hematuria/proteinuria Chronic RF |
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Kickers for Acute Nephritic Syndrome?
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Acute onset of Hematuria
Mild-->Moderate Proteinuria HTN |
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Kickers for Rapidly Progressive GN?
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Acute RF (oliguria/anuria and azotemia)
Nephritis Proteinuria |
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Kickers for Nephrotic Syndrome?
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Heavy Proteinuria
Hypoalbuminemia Severe Edema Hyperlipidemia Lipiduria |
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who are the non-glomerular diseases?
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Renal Tubular Defects
UTI Nephrolithiasis Urinary Tract Obstruction Renal Tumors Non-Glomerular acute/chronic RF |
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Sx's of tubular defects?
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polyuria
nocturia electrolyte disorders |
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Sx's of UTI?
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bacteruria
pyuria can also affect kidney (pyelonephritis) or bladder (cystitis) |
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Main pathogenesis of Glomerular injury?
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IMMUNE-MEDIATED
1. antibodies reacting against glomerulus 2. Ag deposition in glomerulus |
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how do we detect immune complex deposition?
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only IMMUNOFLOURESCENCE
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Ways the glomerulus responds to injury?
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Hypercellularity
BM Thickening Hyalinization and Sclerosis |
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3 parts of the glomerular hypercellularity response?
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Cell Prolif
Leukocyte Infiltration Formation of Crescents |
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Focal vs Diffuse Glomerular Diseases?
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Focal: less than 50% of glomeruli affected
Diffuse: more than 50% of glomeruli affected |
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Global vs Segmental Glomerular Diseases
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Global: most of the individual glomerulus is affected
Segmental: less than half of the individual glomerulus is affected |
