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18 Cards in this Set
- Front
- Back
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Do viruses have enzyme systems
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No
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T/F Viruses use host cellular machinery
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True
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T/F Viruses are living
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False
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Chemical makeup of viruses
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-DNA or RNA genome
-Surrounding capsid -Naked, or surrounded by cell-derived lipid envelope |
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What is capsid composed of?
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Protein capsomeres
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Three virus structures
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Icosahedral
Helical Complex |
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Virus Classification Based On:
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Nucleic Acid Characteristics and Structural Characteristics
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Virus Replication includes:
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Attachment
Penetration/Uncoating Biosynthesis Maturation Release |
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What does attachment determine or influence:
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1) Host/species range of virus
2) Cell/tissue tropism (receptor specificity) of virus 3) Recovery/Prevention (immunity and esp. vaccine development. New antivirals: entry inhibitors) |
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Retraction of receptors, capsid digestion, often in endosomes
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Penetration/Uncoating
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Cellular synthetic processes re-directed, become viral-specific
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Biosynthesis
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Viral components assembled
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Maturation
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Virus extracellular;
a) if enveloped: budding b) if naked: cell dissolution |
Release
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Generally where do RNA viruses replicate?
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Cytoplasm
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Where to DNA viruses replicate?
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Nucleus
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What limits the development of broad-spectrum antivirals?
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Unique mechanisms for nucleic acid replication
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Viral pathogenic mechanisms
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Cell destruction - inhibition of host DNA, RNA and/or protein synthesis, immune-mediated tissue damage
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Alternatives to cell destruction
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Cell transformation
Suppression of Immune mechanisms |
