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15 Cards in this Set
- Front
- Back
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compounds in the peripheral nervous system that serve as neurotranmistters
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- acetylcholine
- norepinephrine - epinephrine |
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the CNS contains how many compounds that serve as neurotransmitters?
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21
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neurotransmitters of the CNS
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- monoamines
- amino acids - purines - opioid peptides - nonopioid peptides - other like acetylcholine, histamine |
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monoamines
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- dopamine
- epinephrine - norephineprine - serotonin |
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amino acids
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- Aspartate
- GABA - glutamate - glycine |
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purines
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- adenosine
- adenosine monosphate - adenosine triphosphate |
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opioid peptides
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- dynorphins
- endorphins - enkephalins |
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nonopioid peptides
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- neurotensin
- oxytocin - somatostatin - Substance P - vasopressin |
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tolerance
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decreased response occurring in the course of prolonged drug use
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[physical dependance
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state in which abrupt dc of rug use will precipitate a withdrawal symptoms
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factors that that contribute to not fully understanding psychotic drugs?
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- lack of adequate animal models
- mentally ill cannot be used in research (only healthy people! ) - not a great knoldge about neurochemicals |
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testing psych drug on healthy people can produce
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paradoxical effect
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when new drug, following can be employed
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- structural abalogs of the new agent is synthesized
- these analogs are run through biochemical and physiological screening testing to determine if they are similar to the parent compound - after serious toxicity has been ruled out, promising agents are tested in humans for possible therapeutic effects |
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side effects to prolonged drug exposure (CNS)
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- drugs taken chronically - the intensity of side effects my decrease while therapeutic effects stay on the same level
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35
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John F. Kennedy
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