Integration Of Metabolism

Front 1

Which of the following is not true regarding type I diabetes? (multiple choice)
1.Insulin levels are elevated in spite of hyperglycemia
2.The liver is actively synthesizing glucose to put into the circulation
3. Insulin production in the pancreas is compromised
4. If untreated the kidney secretes glucose in the urine
5. All of the above
6. 1 and 2
7. 1, 2 and 4

Back 1

1 and 2

Front 2

Which of the following is true regarding type II diabetes (multiple choice)
1. It usually presents itself in adults
2. Insulin production in the pancreas is compromised
3. Tissues are hypersensitive to insulin action
4. It is associated with low caloric intake

Back 2

1. It usually presents itself in adults

Front 3

Type II diabetes can be reversed in many patients by weight loss and exercise (multiple choice)
1. True
2. false

Back 3

1. True

Front 4

The initial source of energy used in an 100 Meter dash is: (multiple choice)
Glucose
ATP
Creatine phosphate
Glycogen
Fatty acids

Back 4

Creatine phosphate

Front 5

What is the energy source with the slowest rate of mobilization during exercise? (multiple choice)
Glucose
ATP
Creatine phosphate
Glycogen
Fatty acids

Back 5

Fatty acids

Front 6

When does a runner begin to feel the maximum amount of pain that is caused by metabolism? (multiple choice)
As fatty acids begin to be used
When glycogen stores are completely depleted
When ketone bodies begin to accumulate in the circulation
When pyruvate is being converted to lactate
All of the above
2, 3 and 4

Back 6

2, 3 and 4

Front 7

Which vitamins are affected by chronic alcoholism? (multiple choice)
Thiamine
Vitamin C
Vitamin A
All of the above

Back 7

All of the above

Front 8

What happens to the insulin/glucagon ratio during a drinking binge when blood alcohol gets elevated? (multiple choice)
It increases significantly
It decreases significantly
No change due to the alcohol

Back 8

It increases significantly

Front 9

What would you predict is the limiting factor in the survival time of a person who is starving?

Back 9

c. the total triglyceride content in the body

Front 10

Which of the following is occuring in a resting individual in the fed state?

Back 10

c. muscle fatty acyl CoA synthetase is active

Front 11

Under euglycemic conditions (normal blood glucose levels) the liver absorbs the majority of the glucose. When insulin is released during hyperglycemia, the tissue which takes up the majority of the glucose is:

Back 11

a. muscle

Front 12

Within an hour of ingesting a meal

Back 12

c. muscle glycogen phosphorylase is dephosphorylated

Front 13

Insulin stimulates glucose uptake in

Back 13

c. Muscle, liver and adipose

Front 14

In prolonged starvation which of the following will not be observed?

Back 14

e. a and d

Front 15

Within an hour of ingesting a meal a variety of signals affect cellular metabolism. Which of the following will NOT be happening?

Back 15

b. acetoacetate production in the liver

Front 16

The first muscle energy source to be consumed during a 100 meter dash is:

Back 16

c. creatine phosphate

Front 17

Proteins that contribute to energy utilization include

Back 17

e. all of the above

Front 18

Alcohol metabolism leads to

Back 18

f. 1, 3 and 4

Front 19

The concentration of leptin in the circulation is a function of

Back 19

b. the amount of body fat

Front 20

Which of the following energy sources is likely to be the limiting factor that leads to the "wall" that marathon runners reach late in the race?

Back 20

c. monosaccharides

Front 21

The following statement is found in wikipedia regarding the microsomal ethanol oxidizing system. "The MEOS pathway requires oxidation of NADH to NAD, which consumes ATP and dissipates heat, thus leading to the hypothesis that long term drinkers see an increase in resting energy expenditure." Why would this be the case?

Back 21

a. MEOS requires NADPH which is generated from NADH

Front 22

Which of these energy sources takes the longest time to provide ATP for use by the muscle?

Back 22

c. triglycerides

Front 23

The role of topoisomerases is to:

Back 23

b. maintain the cellular DNA in a slightly unwound form

Front 24

Which of the following statements regarding replication fidelity is not correct?

Back 24

c. The 5' to 3' exonuclease activity of Pol I is essential for increased fidelity of polymerase activity.

Front 25

In prokaryotes how does the mismatch repair system identity the strand of DNA which has the wrong base incorporated?

Back 25

b. The strand with the incorrect base is not methylated.
c. For a brief period following replication the daughter strand is not methylated

Front 26

Which of the following base substitutions is a transition mutation?

Back 26

c. G to A

Front 27

Which of the following enzymes (proteins) is required for replication of the prokaryotic genome?

Back 27

b. helicase
c. DNA ligase

Front 28

Which of the following is a transversion mutation?

Back 28

a. adenine to thymine
c. Guanine to cytosine

Front 29

Which of the following statements regarding telomeres is correct?

Back 29

a. Telomeres shorten with each round of replication in all eukaryotic cells.
c. Telomeres are extended by an RNA dependent enzyme.

Front 30

Which of the following enzyme activities is not needed in the direct repair of a mutation in the DNA sequence?

Back 30

d. all of the above

Front 31

Which of the following characteristics are common to topoisomerases and recombinases?

Back 31

a. they function as endonucleases
c. active tyrosine residues involved in catalysis

Front 32

What function does the 5' to 3' exonuclease activity of Pol I serve in E. coli?

Back 32

a. remove the RNA primers used to initiate the lagging strand Okazaki fragments
d. remove the primer on the leading strand