Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
What 3 pathways are important biochemical crossroads in energy metabolism?
|
1. Hexose Monophosphate (HMP)
2. Pyruvate 3. AcCoA |
|
What tissues are nutrient distribution centers?
|
Liver + Adipocytes
|
|
What is the function of liver and adipocytes?
|
To store energy-providing substrates during fed states, and make it available for in times of want (fasting).
|
|
List 3 recurrent themes of metabolic regulation:
|
1. Allosteric effects - short
2. Covalent modification - int 3. Enzyme level changes - long |
|
What molecules are typically acted on by allosteric regulation?
|
The enzymes that catalyze rate-limiting, irreversible, steps of commitment in pathways.
|
|
What 5 enzymes are allosterically affected, and what pathway is affected?
|
1. PFK-1 -> glycolysis
2. FBPase-1 -> gluconeogenesis 3. AcCoA Carboxylase -> FA Biosynthesis 4. PDH -> pyruvate metabolism 5. Pyruvate Carboxylase -> pyruvate metabolism |
|
Why is allosteric regulation good?
|
Because it operates on short-term timescale but produces dramatic effets in response to different metabolic circumstances.
|