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25 Cards in this Set
- Front
- Back
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Nortriptyline & other TCAs
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(Elavil)
S, N, anti-HAM, anti-Na |
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Prozac
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(Fluoxetine)
S |
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Zoloft
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(Sertraline)
S |
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Celexa
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(Citalopram)
S |
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Lexapro
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(Escitalopram)
S |
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Paxil
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(Paroxetine)
S, anti-M |
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Effexor
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(Venlafaxine)
S, N |
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Cymbalta
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(Duloxetine)
S, N |
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Wellbutrin
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(Buproprion)
N, D |
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Remeron
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(Mirtazapine)
anti-alpha 2, anti-5HT2, anti-5HT3, anti-H (stinky mnemonic: A to S to S3H) |
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BuSpar
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(Buspirone)
parital 5HT1A-agonist, DA2 agonist |
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Effects of anti-H
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drowsiness, weight gain
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Effects of anti-A
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orthostatic hypotension
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Effects of anti-M
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confusion, dry mouth, constipation, tachycardia, urinary retention, glaucoma
(stinky mnemonic: CDC TUG) |
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Effects of anti-Na
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arrhythmia
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Effects of anti-alpha 2
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blocks NE autoreceptor & increases NE
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Mirtazapine as choice of medication for diabetic?
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Poor choice: causes weight gain, high lipids
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Buproprion as choice for antidepressant for eating disorder patients?
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Poor choice: electrolyte disturbances already increase risk of seizures.
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Emerging evidence indicates that non-response to antidepressants after X days moderately predicts non-response to antidepressant 4-6 weeks later. What is X?
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7 days
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T or F: There is reveal of information processing bias (i.e. patients start recognizing positive emotional stimuli) within 1st week of taking antidepressants, and sometimes after a single dose.
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True
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If depression's symptoms from DSM can be summarized as SIGECAPS, and one S = Sleep, what does the other S stand for, besides Suicidal Ideation?
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Preoccupation with death
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Per DSM, what is the duration of major depression?
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2 weeks
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Name 6 Depression risk factors.
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1) Genetic
2) Early Developmental Trauma 3) Acute Psychosocial stressors: loss of social rank/intimacy 4) Chronic Psychosocial stressors: low social rank/support interpersonal deficits, which increase likelihood of interpersonal stressors, such as: internalizing [neuroticism] or externalizing [antisocial/narcissistic traits] 5) Substance Abuse 6) Organic: cytokines, etc. |
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In general, serotonin activity ________ dopamine activity. This may explain what two clinical observations:
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Serotonin activity decreases dopamine activity.
This may explain why: 1) atypical antipsychotics with 5HT antagonism have less DA antagonism 2) serotonin decreases impulsivity (DA increases impulsivity.) |
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Name key serotonin receptor subtypes and their functions.
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5HT1A - anxiety
5HT2C - antagonism may increase DA, 5HT release in PFC 5HT3 - GI side effects: N/V, diarrhea |
