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51 Cards in this Set
- Front
- Back
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(influenza)
M2 inhibitors only work on |
A type virus
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Examples of m2 inhibitors
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Amantidine and rimantadine
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H5N1 (bird flu) has ... at position... making it poorly adapted to humans.
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Glutamin, position226.
(leucine would cause pandemic) |
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Sialic acids are...
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NA inhibitors
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NA enzyme inhibitors are effective against
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A and B type influenza
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Tamiflu is a ..
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NA inhibitor
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Tamiflu and Relenza(inhaled) inhibit...
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Virion release (NA function)
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Mimivirus contains..
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Genes never found in viruses before
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Viroids/ Virusoids depends on helper viruses?
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Virusoids
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Virusoids are encapsulated by..
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Helper viruses.
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nvCJD causes vacuolation of neural tissue known as..
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Amyloid accumulation
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Prions are highly resistant to digestion by
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Proteinase K
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How is nvCJD spread?
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Orally (growns in tonsils)
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How is nvCJD spread to CNS?
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Enterocytes (macrophages, m cells, dendritic cells?) enhance dissemination.
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Highest prevalence of nc CJD is in which age group?
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20-30
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Methionine at postion 129 causes ?
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early onset kuru
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V129 causes...
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resistance to nvCJD
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Examples of Kinetoplastida (2)
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Leishmania
Trypanosoma |
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Forested rivers and shores
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Gambiense
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Savannah
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Rhondiense
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Vector for trypanosomas
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Tsetse fly
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Trypanosoma man only
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Gambiense
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Trypanosomes:
Flagellated... Live in... Later invade |
Flagellated protozoa
Live in bloodstream later invade CSF |
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Infective stage of trypanosomiasis
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Metacyclic trypomastigotes
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Diagnostic stage of trypanosomiasis
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Trypomastigotes in BLOOD
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Procylic trypomastigotes occur in...
Epimastigotes occur in.. |
1. midgut (tsetse)
2. salivary gland (tsetse) |
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Trypanosomes have a .... coat
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Variant surface glycoprotein coat
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Trypanosomes attach to cell membrane via
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Glycosyl phosphatidyl inositol (gpi)
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Early stage Trypanosomiasis is treated with
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Suramin/ pentamidine
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Late stage trypanosomiasis is treated with...
(after CNF invasion) |
Melarsoprol/ eflorinithin
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Leishmania parasite invade...
And become... |
Macrophages
Become amastigote forms |
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Leishmania parasite transmitted by..
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Sandflies
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Mucocutaenous infection occur mainly in
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Brazil, Bolivia and Peru
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Leishmania is....
And dogs are a key... |
Zoonotic
Dogs key host |
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Sandfly injects..
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Promastigotes
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Antimony based drugs used to treat
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Leishmaniasis
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In which form of leishmaniasis do parasite migrate to vital organs
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Visceral
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HIV is a ...
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retrovirus
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HiV has
+/-ve strand RNA Size? |
+ve single strand RNA
7-11kb |
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HIV is associated with the diseases..
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Lymphoma, sarcoma, carcinoma, immunideficiencies, autoimmune
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HIV has an absence of
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oncogenity
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Which enzymes transforms RNA to DNA (HIV)
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Reverse transcriptase
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Glycoprotein... and ... on suface of HIV cause how many spikes>
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Glycoproteins gp 120 and gp41 cause 72 spikes
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CD4 receptor site on HIV is
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gp120
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Capsid protein and cone shape of DNA by protein...
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p24
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p7 and p9 (HIV) form...
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ribonucleoprotein complex with RNA genome.
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1. reverse transcriptase
2. integrase 3. protease coded by... |
Pol gene.
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HIV viral DNA combines with
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Host DNA in nucleus
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Viral genome copies are quantified in plasma using
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PCR
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Drugs which inhibit reverse transcriptase
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Azidothymidine (AZT)
Didanosine (ddI) |
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Drugs which inhibit Protease
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protease inhibitors, peptidomimetics, interfere with CD4 - gp120 interactioon
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