Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
|
Onset around 50(rare in children), female predominance, hx of chemical exposure, pentazosine, toxic oil, L-tryptophan
|
Scleroderma
|
|
|
What are the localized forms of scleroderma?
|
Linea Sabre and Morphea(erythematous periphery with central shininess)
|
|
|
CREST syndrome?
|
Calcinosis, Reynauds, Esophageal dysmotility, Sclerodactyly, Teleangiectasias, usually with a positive anticentromere Ab and also pulmonary vasculopathy
|
|
|
Symptoms of diffuse scleroderma?
|
Reynauds, puffy fingers, fibrotic skin, ILD, Renal Crisis (tx with ACE I) Dermal Fibrosis
|
|
|
When is Reynauds indicative of Scleroderma?
|
Vasoconstriction which causes ulcerations and autoamputation of the ischemic tissue
|
|
|
What are GI symptoms of Scleroderma?
|
Esophageal dysmotility, watermelon stomach, colonic diverticulitis
|
|
|
Which type of Scleroderma is seen with Renal Disease
|
Diffuse Scleroderma, not crest disease
|
|
|
Which meds are used to treat scleroderma
|
methotrexate, prednisone, cytoxan, cellcept. Artificial tears, Ace I, Proton Pump inhibitors can be used for symptomatic treatment.
|
|
|
Which antibodies are positive in scleroderma?
|
ANA, Anticentromere in localized Scleroderma, Scl70 in 40% of diffuse
|
|
|
Most common inflammatory myopathy?
|
Polymyositis, followed by dermatomyositis, childhood dermatomyositis, overlap, malignancy.
|
|
|
Pathogenesis of polymyositis
|
mainly cellular mediated process resulting in infiltration of cytotoxic CD8+ cells in the endomysium
|
|
|
Pathogenesis of dermatomyositis
|
characterized by perivascular CD4+ T cells &B cell infiltration along with deposition of late complement components (perimysium)
|
|
|
MSK manifestations of derma. and polymyo?
|
Insidious proximal muscle weakness
Bulbar muscle weakness Heliotrope rash of dermatomyositis Gottron’s papules Raynaud’s Arthritis |
|
|
What are the extramuscular manifestations of inflammatory myopathies?
|
fever, fatigue, aspiration, ILD, calcinosis, heliotrope rash, shawl sign rash and gottrens papules in Dermatomyositis,
|
|
|
Whcih antibodies indicate a good prognosis for dermatomyositis/polymyositis?
|
Anti-Mi2
|
|
|
Which antibody indicates a worse prognosis for dermatomyositis/polymyositis
|
Anti-Jo1
|
|
|
How are dermatomyositis and polymyositis diagnosed?
|
gold standard: muscle biopsy, most patients have positive EMG
|
|
|
What are some non causes for noninflammatory myopathies?
|
Hypokalemia, Hypothyroidism, infection, colchicine, PCN, chloroquine, lovastatin, AZT, corticosteroids
|
|
|
anti-Jo1, anti-SRP, dysphagia, myocardial involvement are indicative of what kind of prognosis for inflammatory myopathies?
|
poor outlook
|
|
|
anti-MI2, DM, myositis in overlap, inclusion body myositis are indicative of what kind of prognosis for inflammatory myopathies?
|
good outlook
|
|
|
How are inflammatory myopathies treated?
|
Prednisone 1mg/kg/day
|
|
|
Systemic disease most frequently manifested by dry eyes,dry mouth & arthritis
|
Sjogren's Disease
|
|
|
Pathogenesis of Sjogren's disease?
|
autoimmune destruction of exocrine glands
|
|
|
What is the triad of criteria for Sjogren's?
|
Keratoconjunctivitis Sicca, Xerostomia, Connective Tissue Disease
|
|
|
Which antibodies are positive in Sjogrens?
|
Positive ANA, Positive SS-A, Positive SS-B, and positive RF
|
|
|
How is Sjogren's diagnosed?
|
Could have enlarged Parotid glands. Salivary Gland Biopsy, which shows diffuse CD4+ lymphocytic foci. Also could have increased ESR, hyperglobulinemia, +RF, +ANA, +SSB
|
|
|
How is Sjogren's treated?
|
Treat the symptoms with artificial tears and saliva, hydration, salagen and restasis. Treat systemic symptoms with Plaquenil, Methotrexate, Imuran
|
|
|
Systemic disease most frequently manifested by dry eyes,dry mouth & arthritis
|
Sjogren's Disease
|
|
|
Pathogenesis of Sjogren's disease?
|
autoimmune destruction of exocrine glands
|
|
|
What is the triad of criteria for Sjogren's?
|
Keratoconjunctivitis Sicca, Xerostomia, Connective Tissue Disease
|
|
|
Which antibodies are positive in Sjogrens?
|
Positive ANA, Positive SS-A, Positive SS-B, and positive RF
|
|
|
How is Sjogren's diagnosed?
|
Could have enlarged Parotid glands. Salivary Gland Biopsy, which shows diffuse CD4+ lymphocytic foci. Also could have increased ESR, hyperglobulinemia, +RF, +ANA, +SSB
|
|
|
How is Sjogren's treated?
|
Treat the symptoms with artificial tears and saliva, hydration, salagen and restasis. Treat systemic symptoms with Plaquenil, Methotrexate, Imuran
|
|
|
What are the systemic effects of Sjogren's?
|
Distal RTA, neurologic manifestations, lymphoma, pulmonary disease, joint symptoms
|
