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20 Cards in this Set
- Front
- Back
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How do we Dx contact dermatitis? What is the gold standard?
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-No clinical or lab tests
-Use clinical morphology and course of rash, with appropriate negative patch tests -Gold standard: patch testing |
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What are the characteristics of acute allergic contact dermatitis? chronic?
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-Acute: edematous, erythematous papules and plaques
-Chronic: scaling, lichenification, fissuring, escoriations |
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What medications tend to cause contact dermatitis?
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Neomycin (third most common allergy in country), benzocaine, additives and preservatives
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How do contact dermatitis and urticaria differ immunologically?
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Contact dermititis: Type IV rxn
Urticaria: Type I rxn |
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How do you differentiate acute and chronic urticaria?
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Acute: outbreak lasts less than 6 wks; caused by meds, foods, or infxn
Chronic: outbreak lasts more than 6 wks; cause usually unknown |
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How do you treat contact dermatitis? urticaria?
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Contact dermatitis: topical steroids
Urticaria: antihistamine |
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How would you define a morbilliform drug eruption?
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diffuse blanching erythematous maculopapular
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What kind of immunologic reaction is a morbilliform drug rxn?
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Undefined
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Name four drugs inducing Stevens Johnson syndrome?
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Allopurinol, antibiotics (ex: penicillins, sulfa), anticonvulsants (ex: phenytoin, carbamazepine, barbiturates), NSAIDS
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SJS/TEN may present initially like a morbilliform drug eruption. What are the later stages of the dz?
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macule/papules become purpuric or targetoid, skin tenderness indicated necrosis;. Vesicles and bullae develop. Mucous membranes (ex: hemorrhagic crusting) may become involved indicating severe dz.
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What is follicular hyperkeratosis?
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Overly "sticky" skin that encourages development of keratinous debris and thus acne. Retinoic acid combats acne by desquamating this sticky skin
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Which anaerobic bacteria causes follicular inflammation in acne?
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Propionibacterium acnes
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Describe comedones.
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Comedones are mxture of keratin, sebum, and vellus hairs obstructing pilosebaceous opening.
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Differentiate a closed from an open comedone.
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Open: blackhead, obstruction is superficial and oxidized
Closed: whitehead, obstruction is deep and pore is not open |
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What are 4 side effects of accutane?
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teratogenicity, cheilitis, xerosis, hyperTG
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What is the clinical presentation of rosacea?
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central facial erythema, telangiectasia, papules and pustules, no comedones, eye involvement (keratitis, bepharitis, conjuctivitis), rhinophyma (bulbous nose)
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What Tx should be avoided in rosacea?
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Potent topical steroids
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What is seborrheic dermatitis?
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chronic inflammation of hairy body regions (esp scalp, eyebrows, face) possibly caused by yeast Pityrosporum
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Severe acne in female with hirsutism and irregular menses may suggest...?
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androgen excess (polycystic ovarian syndrome, androgen secreting tumor)
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Aside form supportive therapy, what other therapy might be considered in SJS?
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IVIg. Also consider an ophthalmology consult for these pts.
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