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22 Cards in this Set
- Front
- Back
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What do you see in active colitis?
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Acute/active:
PMNs Pus in the crypts Glowouts of the crypts-->invasion of the lamina propria Chronic: Macrophages Lymphocytes Plasma cells |
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What's associated with more severe IBD?
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Ulcers!
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What are the complications of uncontrollable IBD?
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Hemorrhage
Diarrhea |
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What's always involved in ulcerative colitis?
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Rectum
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What's the definition of left sided colitis?
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Colon is involved all the way up to the splenic flexure
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What macroscopic changes happent ot he colon in ulcerative colitis?
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Loss of transverse folds
Severe hemorrhage Pseudopolyps (made up of inflamed cells) Mucosal granularity |
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What are some histologic signs of ulcerative colitis?
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No 2 crypts are same size, shape, going in same direction: THEY LOOK FUNKY!
Plasmacytosis |
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What's the endpoint of ulcerative colitis?
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Atrophy: complete loss of crypts
Destruction of the nerves that result in a loss of nervous function in the colon-->MEGACOLON! |
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What are the causes of pseudomembranous colitis?
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C. difficile overgrowth due to giving broad spectrum antibiotics
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Whta are complications of ulcers from ulcerative colitis?
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Many large ulcers: uncontrollable hemorrhage/diarrhea
Undermining ulcers: inflammatory pseudopolyps Broad, deep ulcers: megacolon - A BIG COLON! |
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What is the definition of Crohn's disease?
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Chronic ulcerating disease classically involving the small intestine (but can involve any part) that in its fully developed state, involves the whole gut wall.
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What's the choice location of Crohn's?
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Terminal ileum
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What are the types of ulcers in Crohn's diease?
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Aphthous: shallow
Linear: run along bowel longitudinally Fissure: perpendicular, deep ulcers-->fistulas |
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What is a characteristic histologic finding of Crohn's?
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What is a complication of crohns that causes strictures?
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Proliferation of the mucsularis mucosae-->stricutres
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What happens to strictured/diseased intestines?
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Mesenteric fat wrapping
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What are causes of intesitnal ischemic colitis?
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Arterial hypoperfusion due to low flow, arterial blockage
Venous outflow obstruction: congestio and hemorrhage |
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What is the cause of ischemia in toxic megacolon?
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Venous outflow obstruction
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How do you distinguish between ischemic injury and IBD?
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Ischemic:
Lack of inflammatory cells "Pinkish" color Submucosal edema Atrophic patches |
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How do you tell something is pseudomembranous colitis on a slide?
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IT LOOKS LIKE A VOLCANO OF PUS!
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What are the inflammatory colitises that don't cause distortion?
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Lymphocytic
Collagenous |
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Grossly, how do you see lymphocytic colitis?
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You don't!
It's a microscopic diagnosis. |
