Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
35 Cards in this Set
- Front
- Back
|
What do hageman factors do? |
They activate the clotting cascade and the Kinin cascade . It causes clotting and can work in the Kinin/bradykinin/ plasmin/ fibrin system |
|
|
What does bradykinin cause? |
Pain and vascular permeability |
|
|
What does kalikrein cause? |
Activates hangman factor. Chalkier cleaves plasminogen toplasmin which activates clot lysis by cleaving fiber. HF also create costs through fibrin |
|
|
What is the complement cascade? |
Protein cascade that leads to activation of C3 |
|
|
Describe the protein cascade? What is the key step? |
C3 splits to C3a and C3b and then C3a continues to go and split C5 to C5a and C5b and then C5b goes on to activate C5-9 The key step is activation of C3 |
|
|
What does C3a and C5b cause |
vascular dilitation and permeability |
|
|
What does C5-C9 cause |
It induced microbial and cell necrosis |
|
|
What are the mediators in the plasma clotting system> |
Plasmin--> It celaves C3-C5 and activates HF HF- triggers knin cascade and clotting cascade Plasmin- Acts on fibrin to cleave and increase vascular permeability Fibrin is formed---> Vascular occlusion which leads to ischemia and necrosis |
|
|
What is the other name for HF |
Factor XII |
|
|
What does hangman activate |
HF activates Kinin and clotting system and it is activated by kalikrien and plasmin |
|
|
What does chalkier activate? |
HF, Coplement system C3-C5 and fibrinolysis, **It is chemotactic |
|
|
NAme a vasoactice amine, its action and where is it released from> |
Histamine and it is released from last cells/ basophils and it constricts BV resulting in permeability |
|
|
2 preformed cellular factors |
Vasoactive amines and lysosomal constituents |
|
|
Lysosomal constituents is released from what |
Released from POLY and the actin tissue destruction |
|
|
PAF derived from where? |
Cell membrane along with prostaglandins |
|
|
Nickname of PAF |
Ultimate mediator |
|
|
What does PAF do |
Acts as a vasodilator, vascular permeability leading to edema, WBC activation and chemotaxis. Promotes synth of other mediators |
|
|
How do e get Arachidonic acid? 2 pathways |
We get it from Phospholipase 2 and the two pathways are the lipooxygenase and the Cyclooxygenanse pathways |
|
|
actions of the Cyclooxygen pathway and the Lipooxygenase pathways |
Cyclooxygenase- Arachidonic to prostaglandin Lipooxygenase- Arachidonic to Leukotrienes |
|
|
PGD, PGE, PGF, cause what? PGI2?
|
D, E*, F cause fEver I2- VasodIlation |
|
|
leukotriences cause what CDE? B? |
CDE- cause casoconstriction B- Chemotaxis |
|
|
What do corticosteroids prevent? |
Formation of arachidonic acid (Antiinflammatory) |
|
|
What inhibits cyclooxygenase? |
NSAIDS |
|
|
What are cyclooxyrgenases made of?where are they found |
They are made of Cox-1, Cox-2, 1- is found in all cell types while 2- is found mainly in WBC's during inflammation (induced) |
|
|
PGI2 comes from where? PGE2 |
PGI- Endothelium (vasoconstriction)
PGE- macrophages (fever) |
|
|
Leukotrienes are made by? |
WBC's |
|
|
5 lipooxygenase is enhanced by? |
FLAP |
|
|
LT CDE causes? CTB |
CDE- vascular perm B- chemostaxis |
|
|
Cytokines come from? Two groups |
They come from lymphocytes and macrophages . IL1/TNF & IL-6 |
|
|
What do the different 3 cytokines cause |
Il-1/TN-A- fever weight loss and induce ELAM and VCAM. Il-6 Fever |
|
|
Chemokines role |
regulate chemotaxis of cells to site of injury |
|
|
Two macrophages are produced by what, roles of each ? |
eNOS- endothelium iNOS- macrophages eNOS- puts a break on inflammation iNOS- vasodilation |
|
|
Role of free radicals? |
GEnerated in macrophages and they cause damage to tissue. aging/ alter DNA can incite apoptosis |
|
|
What enzyme can limit free radicals? |
Superoxide dimutase |
|
|
What is th main neuropeptide, produces what. What is purinergic signlaing |
Substance P- produces pain and perm purinergic signaling is the ADP/ATP released from Polys that result in clotting. |
