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10 Cards in this Set

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  • Back
Define Granuloma
focus of chronic inflammation consisting of an aggregate of macrophages that tend to look like epithelial cells and coalesce into giant cells surrounded by collar of lympohcytes and occasionally plasma cells
Caseating Granuloma
Immune granuloma (Tb) central necrosis with amophous debris and acid-fast bacili (caseous necrosis)
Noncaseating Ganuloma
Foreign body granuloma (no necrosis)
Lipidogranuloma
Usually occurs after traumatic fat necrosis
List the 2 fates of garnuloma
Persistence (w/ or w/o dystrophic calcification) OR resolve leaving behind a small scar or cavity
List the phases of wound healing
inflammation, organization and regeneration, deposition of ECM, remodeling
explain the difference between first intention and second intention wound healing
1st: organization confined to area first cut (no contraction by fibroblasts)
2nd: open wound fills in with granulation tissues; a little more scarring (surface looks the same though)
name 2 factors of scar formation
1)angiogenesis
2) fibroblasts proliferate and make collagen

Note: scar replaces necrotic tissue, unresolved exudates, and blood clots
Explain the timeline of healing by primary intention
1 day: neutrophils appear and move toward fibrin colt in the wound

3 days: macrophages replace neutrophils and granulation tissue begins to fill the incision

5 days: granulation tissue fills incision with maximal neoangiogenesis and fibroblast proliferation (not a lot of collagen here--wound is at most vulnerable)

2 weeks: fibroblasts continue to accumulate and make collagen scar
What is a plasma cell and what is its role?
It's a cell that differentiates from a B cell. It consists of extensive, well-developed golgi. RER combined with golgi ideal for secreting antibodies