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20 Cards in this Set
- Front
- Back
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Circulating inactive plasma proteases
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Complement
Kinin System Coagulation sys Fibrinolytic sys |
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Pre-formed mediators
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vasoactive amines
WBC lysosomal proteases (definsins, Lysozyme, lactoferrin) |
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Mediators produced in response
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Arachidonic acid, Oxygen free radicales, PAF, NO, Cytokines, Substance P (neuropeptide)
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Chemotaxis
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C5a
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Oponization
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C3b
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Permeability
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C3a, C5a
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WBC activation
increase wbc integrins Upregulation of Lipoxygenase (arachodonic acid) |
C5a
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What is alpha-1-antitrypsin
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antiprotease that holds the "free" lysosomal enzymes in check
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What increases eNOS and nNOS
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calcium
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What increases iNOS
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cytokins such as TNF and INF (iNOS is involved in spetic shock)
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3 actions of Nitric Oxide
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Vasodilation, locally decrease inflamation, increase O2 free radicals to kill bacteria
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3 major inflammatory cytokins
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IL-1 TNF alpha IL-8
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Substance P
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activation of arachidonic acid and increase vascular permeability
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big three vasolilatories
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NO, histamine/serotonin, prostaglandins
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What increases permeability
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Vasoactive amines, leukotriens,PAF, Substance P, bradykinin, C5a, C3a
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what 2 factors are involved in adhesion?
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C5a and IL-1
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What three things activate leukocytes
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TNF, C5a, PAF
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What cytokins are involved in FEVER
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IL1 and TNF alpha
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Give four examples of acute phase protien and the IL that stimulates there release
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C-reactive protein, complement, Serum amyoloid A and fibrinogen. Stimulated by IL-6
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What two things cause pain
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Prostaglandins and bradykinin
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