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20 Cards in this Set

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  • Back
Circulating inactive plasma proteases
Complement
Kinin System
Coagulation sys
Fibrinolytic sys
Pre-formed mediators
vasoactive amines
WBC lysosomal proteases
(definsins, Lysozyme, lactoferrin)
Mediators produced in response
Arachidonic acid, Oxygen free radicales, PAF, NO, Cytokines, Substance P (neuropeptide)
Chemotaxis
C5a
Oponization
C3b
Permeability
C3a, C5a
WBC activation
increase wbc integrins
Upregulation of Lipoxygenase (arachodonic acid)
C5a
What is alpha-1-antitrypsin
antiprotease that holds the "free" lysosomal enzymes in check
What increases eNOS and nNOS
calcium
What increases iNOS
cytokins such as TNF and INF (iNOS is involved in spetic shock)
3 actions of Nitric Oxide
Vasodilation, locally decrease inflamation, increase O2 free radicals to kill bacteria
3 major inflammatory cytokins
IL-1 TNF alpha IL-8
Substance P
activation of arachidonic acid and increase vascular permeability
big three vasolilatories
NO, histamine/serotonin, prostaglandins
What increases permeability
Vasoactive amines, leukotriens,PAF, Substance P, bradykinin, C5a, C3a
what 2 factors are involved in adhesion?
C5a and IL-1
What three things activate leukocytes
TNF, C5a, PAF
What cytokins are involved in FEVER
IL1 and TNF alpha
Give four examples of acute phase protien and the IL that stimulates there release
C-reactive protein, complement, Serum amyoloid A and fibrinogen. Stimulated by IL-6
What two things cause pain
Prostaglandins and bradykinin