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93 Cards in this Set
- Front
- Back
associated with cervical carcinoma
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HSV2
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herpes labialis
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HSV1
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seen in poorer parts of the world and industrialized western nations
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EBV
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CNS abnormalities can lead to cerebral palsy, epilepsy and impaired hearing and sight
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CMV
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pharyngeal erythema and edema
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HSV1
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blood transfusions-most asymptomatic
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CMV
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photophobia
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HSV2
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B-lymphocytes are target cells
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EBV
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Burkitt's lymphoma
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EBV
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oral conact with fomites contaminated with saliva
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CMV
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Linear, double-stranded DNA
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HSV1, HSV2, CMV, EBV
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nasopharyngeal carcinoma
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EBV
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fever as high as 104 degrees
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EBV
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histopathological lesion is internuclear
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HSV1, HSV2, CMV, EBv
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sexually transmitted
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HSV2
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reproduces in host cell nucleus
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HSV1
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infectious mononucleosis
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EBV
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gingivostomatitis
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HSV1
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interstitial cell pneumonia
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CMV
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inguinal lymphadenopathy
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HSV2
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keratoconjunctivitis
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HSV1
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hepatosplenomegaly jaundice
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CMV
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common cause of worldwide infection; 95% of adults seropositive
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EBV
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herpes neonatorum
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HSV2
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pelvic inflammatory disease
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Neisseria gonorrheae
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opthalmia neonatorum
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Neisseria gonorrheae
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most common manifestation of tertiary syphilis
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aortic aneurysm
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inclusion conjunctivitis may be caused by
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adults: swimming in an unchlorinated pool, contact with genital secretions
newborns: during passage through the birth canal. |
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infectious mono.
it is caused by the same virus that causes African Burkitt's Lymphoma |
TRUE
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infectious mono.
the abmormal circulating cells inflicted are T lymphocytes |
FALSE
B lymphocytes |
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infectious mono.
microscopic changes produced in liver changes resemble viral hepatitis |
TRUE
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infectious mono.
exposure in childhood results in asymptomatic infection |
TRUE
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infectious mono.
microscopic changes produced in the lymph nodes resemble hodgkin's disease |
FALSE
(what??) |
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nasopharyngeal carcinoma
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EBV
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sexually transmitted chlamydia produces all of the following problems except:
PID acute epididymitis genital elephantiasis condylomata lata rectal strictures (ouch!) |
CONDYLOMATA LATA
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ulcerated lesions on the penis occure in the acute form of all of the following STD infecrious diseases except:
herpes genitalis infection syphilis chancroid granuloma inguinale gonorrhea |
gonorrhea
(has to do mostly with the balls) |
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infectious mono.
heterophile antibodies are virtually diagnostic |
TRUE
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no chronic carrier state known
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HAV
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possible outcomes of HBV (6)
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transient subclinical infection
acute hepatitis fulminant hepatitis healthy carrier persistent infection chronic active hepatitis |
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most frequent reason for liver transplant in US, may be the leading infectious cause of chronic liver diseases in the western world
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HCV
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superinfection of HBV carrier may be self-limiting or lead to: severe hepatitis w/ high mortality rate & high rate of chronic active hepatitis in survivors
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HDV
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transmission fecal-oral, just like in HAV
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HEV
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STI's, 5 general characteristics
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-worldwide distribution, humans only reservoir for infection
-most produce chronic sequelae, none evoke permanent protective immunity -women suffer disporportionately more from STI than males -most associated with direct sexual contact, a few transmitted verticall in utero (rare) during, or shortly after birth (common) -in most industrialized nations, incidence has been declining for many years |
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various stresses may periodically reactivate disease which manifests as a cluster of vesicles around the mucocutaneous junction of the lips
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HSV1
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2nd most common STD
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gonorrhea
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herpes labialis
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HSV1
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genital herpes
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HSV2
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common worldwide, 90-95% of people are seropositive
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EBV
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most prevalent STI in the US (20-30 milion affected)
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HPV, anogenital warts/Condyloma acuminatum
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virus ascends lumbar and sacral sensory ganglia
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HSV2
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primary infection may be subclinical but severe disease often occurs, especially in females; oncogenic potential in association with cervical carcinoma
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HSV2
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greatest risk of intrapartum infection associated with active primary maternal infection, herpes neonatorum
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HSV2
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asceptic meningitis- usually mild and self-limiting
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HSV2
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transmission usually via oral contact-kissing. virus present in saliva and B cells
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EBV
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incubation 4-7 weeks
40 days with oral contraction 2wks with intravenous contraction |
infectious mononucleosis/glandular fever
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target cell B lymphocytes
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infectious mononucleosis
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cytomegalovirus/CMV
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HHV5
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are adults with CMV asymptomatic?
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NO
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perinatal infection aquired during delivery or from breast milk
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CMV
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clinically, resembles EBV mononucleosis but does not include pharyngitis, lymphadenopathy and heterophile antibody
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CMV mononucleosis
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once infected, after recovery, virus sheds sporadically for life in saliva and other secretions
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CMV mononucleosis
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oral contact with fomites contaminated with saliva transmits disease
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CMV mononucleosis
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infection of basal cells in stratified squamous epithelium, local proliferation, KOILOCYTOSIS (enlarged vacuolated cytoplasm with shrunken nuclei), lesions in women in transmormation zone b/n cervix & uterus.
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HPV
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atypical forms- flat, assc w/ risk of cervical, penile & anal carcinoma
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anogenital warts/condyloma acuminatum (HPV)
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type 16 accounts for half of cancer cases in US and Europe
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HPV (anogenital warts)
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DNA viruses
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have oncogenic potential, can get into DNA
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what STI is similar to HBV?
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AIDS, secreted in breast milk (virus shed in breast milk)
blood borne |
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target cells are those with CD4 receptors (Tcells, macrophages, monocytes & LANGERHANS CELLS)
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AIDS/HIV
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likely vehicles for transport of HIC to lymph nodes and CNS
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macrophages and monocytes
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primary reservoir of infectious HIV virus
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lymph nodes
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middle/chronic/latent phase of AIDS/HIV
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viral replication continues predominantly in lymphoid tissues, 7-10 yrs
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final/crisis phase of AIDS/HIV
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collapse of host defenses, increase in viremia, prolonged fever, fatique, wt loss, diarrhea.
CD4 cell count <500 (considered AIDS if <200) |
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AIDS related conditions
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-kaposi's sarcoma
-B cell lymphomas -cervical cancer |
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AIDS indicator infections (account for 80% of mortality)
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-pneumocystis jiroveci (nee carinii) pneumonia (PCP)
-toxoplasmosis -cryptosporidiosis -candidiasis (C. albicans) -cryptococccis, Histoplasmosis, Coccidioidomycosis -CNV -HSV -Mycobacteriosis |
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leading cause of death amongs HIV positive in some african nations
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TB
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untreated disease spreads to posterior urethra & major glands of genital tract (prostate, seminal vesicles, epididymis, but NOT testis) NO orchitis
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gonorrhea
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may cause STERILITY, gonococcemia and arthritis
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gonorrhea
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most infections are genital but, rectal and pharyngeal also seen
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gonorrhea
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world's leading cause of treatable blindness
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trachoma (infection caused by strain of Chlamydia trachomatis)
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inclusion conjunctivitis- in newborns (passage through canal) & adults (unclorinated pools)
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an infection caused by a strain of Chlamydia trachomatis
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worst case scenario: blocked lymph nodes may lead to elephantiasis of the genitalia, esp. in women
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Lymphogranuloma Venereum (LGV) (caused by Chlamydia)
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syphilis, is a disease of...
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blood vessels and perivascular areas: inflammation nof blood vessel endothelium blocks arteriole lumen causing obliterative endarteritis which underlies all damage seen
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primary lesion of syphilis
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chancre, typically on male penis, female vulva or cervix
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condylomata lata
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flat, reddish brown elevations, 2-3cm diameter with many organisms, appear around moist areas.
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syphilis latent phase
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most infections never progress beyond this point
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syphilis tertiary phase involves...
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-CV system most commonly, aortic aneurysm
-neurosyphilis -SYPHILITIC GUMMA=localized lesions of liver, bones, testes, skin with characteristic rubbery, necrotic center. |
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Non syphilitic treponematoses
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increasingly rare skin diseases geographically resricted to tropics, caused by organisms morphologically identical to T. pallidum. Evoke cross reacting antibodies, spread by non-venereal direct contact, no transplacental transmission.
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congenital syphilis, marasmic infant
characteristic triad |
1-interstitial keratitis and choroiditis
2-Hutchinson teeth (barrel incisors) 3-8th cranial nerve deafness |
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Pinta lesions
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most commonly occur on hands, feet, and scalp. initially hyperpigmented, later depigmented in tertiary stage
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Bejel
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caused by Treponema pallidum endicum (endemic syphilis)
-lesions in oral cavity |
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chancroid (soft chancre) ulcers
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may predispose one to infection with HIV
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small blisters (strawberry mucosa)
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Trichomoniasis (a protozoan infection)
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loss of normal vaginal acidity predisposes one to symptomatic infection
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trichomoniasis
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