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9 Cards in this Set
- Front
- Back
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What are the 3 functions of reverse transcriptase?
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1. Acts as a RNA-dependent DNA-polymerase
2. Destroys the RNA template - RNAse H 3. Makes a second strand of DNA polymerase: DNA dependent DNA polymerase |
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How do viruses cause cancer?
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1. Some encode for oncogenese
2. Site of provirus insert can be oncogenic (driven by viral promoter) 3. Virus may encode transactivator that activate viral and oncogene promoters |
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What are the 2 proteins on the surface on the envelope of influenza virus? What are the functions?
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1. Haemaglutinin - attachment and fusion of virus to cell.
2. Neuraminidase - cleaves sialic acid & facilitates release of virus from infected cells. |
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Which one of the following types of influenza that can cause shift or drift.:
- Influenza A, B, C |
Influenza A - shift and linear drift
Influenza B & C - drift only |
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What are the 2 main drugs for influenza? Describe briefly their mode of actions.
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1. Amantidine/rimantidine - interfere with viral M2 protein -> prevent uncoating
2. Zanamivir/oseltamivir - sialic acid analogue, inhibits viral neuraminidase preventing release of new viral particles. |
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What are the 3 enzymes in HIV?
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1. Protease
2. Integrase 3. Reverse transcriptase |
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What are the symptoms will define AIDS?
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- Pneumocystis pneumonia (pneumocystic jiroveci)
- Toxoplasmosis - Kaposi's sarcoma - Mycobacterium avium complex - Invasive cervical cancer |
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How do you diagnose HIV?
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ELISA (EIA)
Western blot - gold standard |
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What are the antibiotics of the protein synthesis inhibitors?
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buy AT 30 CELL 50
30 - Aminoglycoside - Tetracycline 50 - Clindamycin - Erythromycin (macrolide) - Lincosamide - Linezolid |
