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29 Cards in this Set

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DDx of skin infections

- impetigo


- scalded skin syndrome


- cellulitis


- erysipelas

4

DDx of a swollen leg

- DVT


- cellulitis


- myositis


- fasciitis


- haematoma


- muscle injury


- compartment syndrome

DDx in cellulitis

- vasculitis: erythema nodosum


- post-phlebitic limb: chronic venous insufficiency


- eczema: atopic, contact


- venous insufficiency: venous eczema, often bilateral, yellow crusting, scaling


- thrombophlebitis: swelling along path of vein, chronic skin discolouration, typically no erythema or discomfort


- DVT: unilateral swelling of >3cm

6



Cellulitis

Definition of cellulitis

Bacterial infection of the skin and subcutaneous tissue


- most commonly affects the legs

Definition of erysipelas

An acute, superficial form of cellulitis that involves the dermis and upper subcutaneous tissue


- has a well defined, red, raised border

Classical features of cellulitis

- erythema


- heat


- swelling


- pain




- features of severe infection: fever, malaise, chills, lymphangitic spread, disproportionate pain



4

Lesions in cellulitis

- erythematous


- oedematous


- tender


- regional lymphadenopathy


- vesicles/bullae


- entry wound/pre-existing skin pathology

6

Investigations in cellulitis

- leukocytosis


- raised inflammatory markers


- swab skin for organism

3

Predisposing causes of cellulitis

- PVD: leg ulcer, eczema, oedema


- immunosuppression: HIV, steroid therapy, DM


- systemic illness


- chronic kidney disease


- chronic liver disease


- skin break: entry point for infection, e.g. insect bite


- recent surgery


- tinea pedis


- obesity

4

Causative agents in cellulitis

- beta haemolytic streptococci (group A, strep pyogenes)


- staph aureus

2

Assessing cellulitis severity

- class I: no systemic toxicity/co-morbidity


- class II: systemically ill/co-morbidity


- class III: marked systemic illness/severe co-morbidity


- class IV: sepsis syndrome/life threatening infection (necrotising fasciitis)

4

Management of cellulitis

- elevate affected limb


- analgesia & antipyretics


- hydration


- mark extent of erythema


- non-adherent saline dressings if weeping


- antibiotics: benzylpenicillin, flucloxacillin (clindamycin if penicillin allergy)

3

Antibiotics in cellulitis

Flucloxacillin or benzylpenicillin (clindamycin if allergic to penicillin)


- class I: flucloxacillin 500mg QDS (covers both organisms)


- class II/III: flucloxacillin 2g QDS


- class IV: IV benzylpenicillin & co-amoxiclav

Complications of cellulitis

- local necrosis


- abscess


- septicaemia

3

Necrotising fasciitis

Definition of necrotising fasciitis

A rapidly spreading infection of deep fascia with secondary tissue necrosis (may involve underlying muscle)


- leads to massive tissue loss, multiorgan failure & death rapidly

Bacteria in necrotising fasciitis

Can be single microbe or polymicrobial




- group A haemolytic streptococci


- staph aureus




Anaerobes (form gas gangrene)


- clostridium perfringens


- bacteroides

4

Risk factors for necrotising fasciitis

50% of cases occur in young healthy individuals


- abdominal surgery


- immunosuppression: DM


- haematological malignancies


- IV drug use

3

Presentation of necrotising fasciitis

- severe pain: may be no visible skin changes


- erythematous, blistering skin


- systemically unwell


- surgical emphysema

5

Investigations in necrotising fasciitis

- FBC: decreased WCC


- U&Es: increased urea, hyponatraemia


- inflammatory markers: increased CRP


- creatine kinase: >600


- x-ray: soft tissue gas may be present

5

Management of necrotising fasciitis

- urgent referral for extensive surgical debridement


- empiric broad spectrum IV ABx


- ICU management

3

Prognosis in necrotising fasciitis

Mortality is up to 76%

Bullous impetigo

Non-bullous impetigo

Definition of impetigo

A common, highly contagious, superficial bacterial skin infection caused by staph epidermis (bullous impetigo), staph aureus (incl. MRSA), or streptococci (non-bullous impetigo)

Definition of scalded skin syndrome

An exfoliating condition that affects children, particularly neonates, caused by staph aureus



Folliculitis

Definition of folliculitis

Infection of hair follicles caused by staph aureus


- a subtype of impetigo