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202 Cards in this Set

  • Front
  • Back
a TOXIC EFFECT is any irreversible harmful effect on the body as a result of contact with a substance via the respiratory tract, skin, eye, mouth, or other route T or F?
False, its reversable or irriversable

A good example of a substance that has unique effects on multiple organ is organic lead T or F?

False, Inorganic lead

LETHAL CONCENTRATION is usually expressed as milligrams per kilogram or ppm T or F?
False, milligrams per cubic meter.
LETHAL DOSE is milligrams per kilogram or ppm.
The response to a new chemical can be assumed by the analogous to that produced by contact with a substance having a similar chemical and biological structure T or F?
True
One of the shortcomings of air standards is the difficulty in acquiring a truly representative breathing zone sample T or F?
True
Considered a central nervous system depressant?
Acetone

The total amount of a toxic compound absorbed via respiratory pathways depends on __________?

- It's CONCENTRATION in the air


- Pulmonary VENTALLATION problems


- The DURATION of exposure

In addition to providing the EPA with test data and other information about the safety of a new chemical, a company is required to notify the EPA _______ before starting to manufacture the chemical?
90 days
According to the ACGIH's rating system for carcinogenic substances, a substance with a rating of A4 is _______?
Not classified as a human carcinogen
Acetone may be detected using either a urine sample or a blood sample T or F?
True
The cutaneous absorption rate of some organic chemicals increases when ______and ______ increase?
Temperature and Perspiration

The dose-response relationship can be expressed as the product of two variables. What are these varibles?

Concentration (C) and Duration (T)

The occurrence of the usual health effects caused by a substance following exposure to air levels below those associated with effects to most individuals?
Hypersusceptibility
According to in NIOSH, when should a substance be considered as SUSPECTED carcinogen to humans?
If it produces cancers in two or more animal species.
If epidemiological data and cases of human exposure are not available for study, what is the preferred method for determining TLV's?
Longterm inhalation test studies involving several animal species at concentrations both above and below the lowest effect level.
Rates of _____, ______ and _____ determine when it is most appropriate to analyze biological samples in relation to duration and time of exposure?
absorption, metabolism, and excretion
What types of samples are used to determine BIOLOGICAL EXPOSURE INDICES?
-Urine
-Blood
-Expired air
Is the ABILITY of a substance to cause an unwanted effect when the substance has reached a sufficient concentration at a certain site in the body ?
Toxicity
Is the PROPABILITY that a concentration will occur at a certain site in the body?
Hazard
Toxicity, along with the chemical and physical properties of a substance, determine the level or degree of a hazard T or F?
True
A toxic substance can enter the body by more than one route depending on its specific properties T or F?
True
Although all substances produced harmful effects at some dose, a toxic substance causes harmful effects at low doses?
True
Irritation from airborne contaminates is generally reversible after short-term exposure T or F ?
True
Animal testing is an accurate and easy means of measuring the toxicity of a chemical for humans and determining acceptable Threshold Limit Values T or F?
False
If a substance is not included on the Toxic Substances List, the substance is not toxic
T or F ?
False
Factors used to determine the degree of hazard of a toxic substance?
-Route of Entry
-Enviornmental varibles
-Physiological state

Prolonged exposure is typically defined as


____, ____ , or ____ weeks?

2, 4, or 6 weeks

Carbon monoxide is NOT a simple asphyxiant


T or F?

True, cause its a chemical asphyxiant

DESCRIPTIVE human epidemiological data identifies a change in prevalence of a disease in a subgroup of a population T or F ?
True

______ ______ measures the composition of the external environment surrounding the worker?

Air monitoring

Irritants are often grouped according to their site of action T or F?
True
The toxicity of a chemical depends on _______?
The degree of EXPOSURE and ABSORPTION
What is the "Hazcom" or "right-to-know" regulation?
29 CFR 1910.1200
Hazard Communication Standard
With 2 or more hazardous substances that act on the same body organ system are present, primary consideration should be given to ________?
Their combined effect
When filling out a Material Safety Data Sheet for a substance made from ingredients that are a trade secret, is a company required to name the ingredients?
No, the company can withhold the names of the ingredients, but it must disclose their hazardous properties, if any exist.

The Dose of a substance that is expected to kill 50% of a defined experimental animal population, as determined from exposure to the substance by any route other than inhalation?

LD50

The concentration that produces no death in an experimental group and is the highest concentration tolerated in animals and is rarely used?
LD0
The lowest concentration that kills 100% of the exposed animals?
LD100
Can biological sampling be used in place of air sampling?
Yes, but it should not be substituted for air sampling
Measures the amount of chemical absorbed via any route(lungs, skin, mucus, etc.) as well as the effects of added stress. It shows the total exposure both on and off the job to harmful chemicals
Biological Sampling

What is the TSCA? It is administered by the Enviornmental Protection Agency (EPA)

Toxic Substances Control Act

What are the Federal Regulations Covering Industrial Toxicology?
-OSHAct
-Toxic Substances Control Act
-NIOSH / OSHA Standards
The health effect of a chemical exposure is considered "acute" if it ______ ?
is relatively short-lived
An agent that affects only the developing fetus?
Teratogen
An agent that affects the genetic material of an exposed organism?
Mutagen
A primary amyl alcohol. The substance in alcohol that makes you feel drunk?
Isoamyl alcohol
Ethyl Alcohol
Ethanol
What ethanol becomes after it metabolises in the body?
Acetaldehyde
______% of ETHYL ALCOHOL is absorbed in the stomach and ______% is absorbed in the lower intestine?
20% in stomach and 80% in lower intestine
A synthetic, deadly and ABSORBS rapidly in the grouin area of the body. It enters the central nervous system and is deadly.
Phenol; used in plastics, disinfectants, slimicide, meds ( campophenic, throat lozenges)
Highly acute toxin, known as a probable human carcinogen, can be INGESTED, affects the lungs and takes very little to kill you. Used in the rubber industry. 50-500ml per kilogram (2.2 Ibs) of body weight.
Aniline
Why is inhalation the most important route of entry for the human body?
Because any airborne substance can be inhaled quickly due to us breathing
ROE is an important factor to the toxicity of a substance T or F?
True
Most widely used substance throughout the industry, weak acid until it contacts water. Key component in batteries, waste water treatment, & manufacturing fertilizer.
Sulfuric acid
Used in coke, can be drunk?
Phosphoric acid
(C) concentration x (T) duration = ?
Toxicity

Refers to the ability of a chemical to cause harm to an organism as a result of REPEATED EXPOSURE OVER LONG PERIODS OF TIME?

Chronic toxicity

A substance that affects the part of the body it touches over a period of time (ex. sunlight, creosote)
Chronic local
A substance that effects the part of the body it touches in a short period of time?
Acute local
Absorption and distribution of a toxicant to a site beyond what it touches?
Systemic

A substance that affects a part of the body other than the one it touches (ex. syenide, bee sting, carbon monoxide, H2S)

Acute systemic

A substance that affects the body other than the one that it touches over a long period of time?
Chronic systemic
IDLH
Immediately Dangerous to Life and Health

If a manufacturer intends to introduce a new chemical, it is required by law to test the substance on animals such as rabbits, mice and rats T or F?

True

Concentration of a chemical in air exposed for 4 hours to kill 50% of animals by INHALATION.
LC50
The maximum concentration of a chemical that you may be exposed to 8 hours a day, 40 hours a week over your working life time with no ill effects from nearly all workers
TLV's / PEL's

An inert odorless gas that makes up 79% of our atmosphere. It is used for purging permanently mounted gages like corrosion, flow controllers, purge systems of oxygen, and in tanks to prevent explosions due to flammable vapors?

Nitrogen

O2 compromises what percent of the air we breathe? At what percent does an atmosphere become oxygen deficient?

-Compromises 21% of the air we breathe.


-Becomes oxygen deficient at 16% at sea level

Nitrogen (N2) gas hazards are not limited to the inside of confined spaces T or F ?

True

The American Petroleum Institute (API) is the oil industries leading training organization T of F ?

True

The percent of oxygen in the air is exactly the same in Beaumont, Texas, as it is in Denver, Colorado T or F?

True

The total pressure pushing down on us in Beaumont Texas today is ______mm Mercury and it is ______mm Mercury in colorado?

770mm Mercury in Bmt and 760mm Mercury in Colorado.

Since the pressure due to oxygen in Denver is less than the pressure due to oxygen in Beaumont, you have to breathe faster to get the same amount of oxygen in your lungs T or F?

True

The % of oxygen at the top of Mt. Everest is_____?

20.9%

Solvents are good for cleaning materials, but should not be used to transport solutes T or F?

False

In general, their is a high potential hazard for inhaling vapors from aqueous solutions T or F?

False

Water is a highly polar solvent T or F?

True

In the US, TLV's have been adopted as a legal standard T or F?

False

Benzene is now indicated as a leukemogenic agent, which has greatly increased its use as a solvent T or F?

False

All alcohols are formed by the replacement of one or more hydrogen atoms by one or more hydroxyl groups T or F?

True

A ______ is a formless fluid that completely fills its container and that exerts at equal pressure in all directions?

Gas

Vapor pressure is highly dependent on _______?

Temperature

Compounds with only carbon and hydrogen atoms are called ________?

Hydrocarbons

The ______ of a LIQUID is the lowest temperature at which it gives off enough vapor to form an ignitable mixture with the air near the surface of the liquid?

Flash point

Sophoric acid is most likely to be an upper respiratory tract irritant T or F ?

True

_____% is the minimum percentage of atmospheric oxygen required to support life?

18 percent

What are the 3 fundamental states of matter?

- gases


- liquids


- solids

What are the most commonly used guidelines in the United States to assist industrial hygienist in interpreting the hazard posed by specific concentrations of gases and vapors in the workplace?

- TLV's


- PEL's


- REL's

What is a functional group in an organic molecule?

A region where reactions can take place

Name at least one reference manual used for classifying and understanding the composition of a SOLVENT?

The Merk Index

Organic chemistry is the chemistry of the compound of oxygen T or F?

False

Esters should never be used as an anesthetic T or F?

True

The greatest safety hazard of saturated and unsaturated alkyl esthers is that they have a tendency to form explosive peroxidesT or F?

True

Respirators can be used as the primary or only means of protection against hazardous chemicals T or F?

False

Hydrocarbons are a major factor in the formation of photochemical smog T or F?

True

The ANSI Z87.1 standard has removed the prohibition on contact lenses in eye hazard areas T or F?

True

Barrier creams are every bit as effective as impervious gloves T or F?

False

The fire point of a liquid is usually about _____ the flash point temperature?

5 F above

Which of the following is a chemical asphyxiant?


-nitrogen


-hydrogen


-carbon monoxide


-carbon dioxide

Carbon monoxide

Aliphatic compounds take their name from the Greek word aliphe, meaning ______?

Fat

It is estimated that there are _____ different hydrocarbons in gasoline?

500

Which of the following have been used as anesthetics?


- cyclic hydrocarbons


- aliphatic hydrocarbons


- lipophilic solvents


- none of the above

Cyclic hydrocarbons

Which of the following is an important solvent for acetate rayon and vinyl resin coatings?


- aldehydes


- methanol alcohol


- nitrohydrocarbons


- ketones

Ketones

What does NTP stand for?

Normal tempature (25°C) and


pressure (1 atmosphere)

What are the 8 classifications for common organic solvents?

-aliphatic


-cyclic


-aromatic


-halogenated hydrocarbons


-ketones


-esters


-alcohols


-ethers

What elements make up the halogens?

-flourine


-chlorine


-bromine


-iodine


-astatine

Methanol is one of the two most important industrial alcohols. What are some effects of its exposure?

Methanol causes several types of injuries, notably impairment of vision and injury of the optic nerve

Ethanol is one of the two most important industrial alcohols. What are some effects of its exposure?

Ethanol is quickly metabolized in the body and largely converted to carbon dioxide, and is the least toxic of the alcohols. The undesirable effects of ethanol primarily are related to its recreational use, as it acts as a depressant, slowing down the central nervous system.

The primary route of exposure for most hazardous particulate is inhalation T or F?

True

The number of asbestos fibers inhaled is not as important as the mass T or F?

False

The relative toxicity of the six forms of asbestos remains in debate T or F?

True

Most particles demonstrate toxicity only when they are deposited in the alveolar region of the respiratory tract T or F?

False

Excess cancer rates have been associated with living in houses with high levels of radon daughters T or F?

False

Both of the main analytical methods available for free crystalline silica are quite imprecise by industrial hygiene standards T or F?

True

Particles in a wide range of sizes are found in a


polydisperse particle cloud T or F?

True

Why is the aerodynamic equivalent diameter of a particle important?

It determines where in the respiratory tract the particle is most likely to be deposited.

What is one of the few particulate matters (PM's) that is routinely analyzed by size -selective microscopic counting?

Asbestos

Where are asbestos exposure and monitoring mostly found?

Building maintenance and renovation

Small (less than 100 micrometers in diameter) peices of solid materials, liquid droplets, or microbiologocal organisms?

Particulate matter

What is the most common method for differential fiber counting in asbestos sampling?

Transmission Electron Microscopy (TEM)

The environmental limit for exposure of the general population to particulate matter are generally much lower than the occupational limit T of F?

True

OSHA requires pre-exposure medical assessment for workers who will be exposed to certain hazardous particulates T or F?

False

The majority of occupational exposure limits are based on the results of air sampling T or F?

True

Diesel exhaust has been shown to be carcinogenic T or F?

True

It is unusual for an industrial hygienist to be asked to sample for infectious airborne bacteria, fungal spores, or viruses T or F?

True

Which of the followig is often a primary factor for the toxicity of a material?


- size of particles


- number of particles


- length of exposure


- chemical composition

Chemical composition

What regulates most U.S. exposure levels for particulate matter?


-OSHA PELs


-NIOSH RELs


-AIHA WEELs


-ACGIH TLVs

OSHA PELs

Most samples taken to assess exposure to particular matter are _______?

Air samples

What work force is especially subject to radon progeny exposure?

Mining

The accumulation of dust in the lungs and the tissue reaction to its presence?

Pneumoconiosis

A value never to exceed even for a short time?

Ceiling limit

A type of scarring of the lung tissue, which results in loss of flexibility, difficulty breathing, and in severe cases, damage to the right side of the heart as it tries to compensate for reduced blood oxygen?

Fibrosis

What biological organisms are most often of interest to the typical industrial hygienist?

- bacteria


- fungus


- viruses

Noise does not always have particular physical characteristics that distinguish it from wanted sound T or F?

True

The sound power radiated from a source remains constant even though intensity diminishes as the distance from the source increases T or F?

True

An individual's ability to hear sentences and repeat them correctly in a quiet environment is not satisfactory evidence of adequate hearing ability because it does not demonstrate the person's ability to hear pure tones T or F?

False

Sound can be transmitted to the inner ear by hearing protective devices, such as earplugs and earmuffs T or F?

True

A hearing conservation program becomes mandatory at an 8-hour TWA exposure of 90 dBA


T or F?

False, 85 dBA

The following statement does not apply to frequencies?


"Broadband noise can be somewhat more harmful than single frequencies" T or F?

True

What is the answer to the following equation:


75 dB + 71 dB = ?

76 dB

Most damage risk criteria are written for _____ _____ because it is the easiest to define in terms of amplitude, frequency content, and duration?

Continuous noise

Which of the following protective devices can reduce bone-conducted sound?


-earmuffs


-earplugs


-canal caps


-helmets

Helmets

Which of the following Industries is not covered by the Hearing Conservation Amendment?


-agriculture


-gas well drilling


-construction


-all the above

All the above

A hearing impairment of one or both ears, partial or complete, that results from one's employment?

Occupational Hearing Loss

Changing the frequency of a sound changes its relative loudness. Why?

Because the human ear is more sensitive to the higher frequencies of sound.

If an employee has experienced a standard threshold shift (STS), a protective device must reduce his or her level of noise exposure to ______ or below?

85 dBA

A wall is not an effective shield against low frequency sounds, but it can offer more protection against high frequency sounds T or F?

True

Doubling sound pressure is the equivalent of doubling sound power T or F?

False

The range of greatest interest in most noise measurements is between 20 Hz and 20,000 Hz. T or F?

False

OSHA sets specific standards for noise generating equipment. These standards can be used as one type of administrative control for noise hazards T or F?

False

A biological check of an audiometer is done by testing the hearing of a person whose hearing threshold is known and stable T or F?

True

The following is true of noise-induced hearing loss:


it usually affects one ear in the extent and degree of loss T of F?

False, it usually affects both ears equally

The threshold of hearing can vary as much as


_____ dB among healthy individuals?

10 dB

Which of the following is a critical factor in the analysis of noise exposure?


- the frequency composition


- the duration of noise exposure


- the A-weighted sound level


- all the above

All the above

If the noise level around a workstation is never greater than _____, the employees noise exposure can be considered satisfactory?

85 dBA

What is the best hearing protective equipment for a worker who is only exposed to hazardous noise intermittently?

Earmuffs

What is a practical way of measuring the noise exposure of workers who perform a variety of tasks in different locations?

A noise dosimeter

The weakest sound that can be heard by a person with very good hearing in an extremely quiet location?

Threshold of hearing

What is the one serious drawback of earplugs and earmuffs as hearing protective devices?

They do not reduce or eliminate a noise hazard

The upper limit of frequency at which airborne sounds can be heard depends primarily on the _____ and ______?

Condition of a persons hearing &


Intensity

Denotes injury to these sensor neural elements of the inner ear. It is produced by one or a few exposures to sudden intense acoustic forms of energy resulting from blasts and explosions or by direct trauma to the head or earm?

Acoustic trauma

Describes the cumulative permanent loss of hearing- Always of the sensorineural type that develops over months or years of hazardous noise exposure?

Noise-induced hearing loss

Refers to non audible acoustic phenomenon that are recognized by the tactile experience of touch, or feeling?

Vibration

Refers to the form of energy that produces a sensation perceived by the sense of hearing in humans?

Sound

Every noise problem can be broken down into three parts. What are these parts?

- the SOURCE that radiates the sound energy


- the PATH along which the sound energy travels


- the RECEIVER

Rate at which pressure oscillations are produced. One hertz is equivalent to one cycle per second. A subjective characteristic of sound related to frequency is pitch.

Frequency (in Hz)

The frequency measured in cycles per second?

Hertz (1cycle per second = 1Hz)

Loudness based on human ear response?

dBA

The preffered unit to measure sound?

Decibel (dB)

The loudness of sound?

Amplitude

Not caused by noise exposure, but by any disorder in a middle or external ear that prevents sound from reaching the inner ear?

Conductive hearing loss

Divides the middle ear from the inner ear?

Oval window

When an entire audiogram decreases due to noise but returns to normal after a period of rest?

Temporary Threshold Shift

The snail shaped part of the inner ear?

Cochlea

A reduction in a person's level of hearing?

Threshold Shift

Found in the inner ear, it regulates balance for the body?

Vestibular system

Suggested baseline of noise tolerance; which if not exceeded, should result in no hearing loss due to noise?

Damage Risk Criteria

An organic chemical compound that is soluble in water. It is a component of products derived from coal and petroleum. It is found in gasoline and other fuels?

Benzene

Anything with a PH of 2 or <

Acid

Helped write a safety text book and worked at Lamar University?

John Montgomery

OSHA states that you can never be exposed to


115 dB? T or F

True

Actual sound level pressure?

dBC

Rythmatic means of average between the dBA and dBC?

dBB

ADD

Average Daily Dose

What standard is 1910.95?

Occulational noise exposure

A naturally occurring mineral. Found in the air anywhere.

Asbestos

Lethal concentration (LC) is used for ______ ______?

airborne materials

______ ______ usually pertains to acute effects and rapid death ( minutes or hours)

Lethal dose

______ ______ is material that exerts little systemic toxic action, either because the products formed on the tissue of the respiratory tract or nontoxic or because the irritant action at the contact site is far greater than any systemic toxic action?

Primary irritant

______ ______ produces irritant action on mucous membranes, but this effect is overshadowed by systemic effects resulting from absorption?

Secondary irritants

______ ______ or illness is characterized by symptoms or disease of long duration or frequent recurrence?

Chronic effects

______ ______ refers to continued or repeated exposure over a prolonged period, usually years?

Chronic exposure

______ is an inflammation or aggravation of the tissue the substance contacts?

Irritation

Allergy, also known medically as ______, is often confused with hypersusceptibility?

Hypersensitivity

Anything with a PH of 12 or > is very ______ to the body.

Corrosive

A substance that causes visible destruction or permanent changes in human skin at the site of contact?

Corrosive

A substance that dissolves another substance?

Solvent

Chemical compound containing the hydroxyl group, one that releases a hydroxy when dissolved?

Hydroxides

Use this simplified schedule to add decibels

:) :) :) :)

Chemicals that contain carbon?

Organic compound

Chemicals used to designate compounds that generally do NOT contain carbon, whose source is matter other than vegetable or animal?

Inorganic compound

Fields of chemistry?

-Organic


-Inorganic


-Physical


-Bio