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101 Cards in this Set
- Front
- Back
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Methicillin
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Interstitial nephritis
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Amoxicillin
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pseudomembranous colitis
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Imipenem
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CNS toxicity - seizures w/ high plasma levels
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Vancomycin
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RED MAN - diffuse flushing
Nephro Oto Thrombophlebitis |
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Amingoglycosides
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Nephro (esp w/ cephalopsorins)
Oto (esp w/ loops) Teratogen |
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Tetracyclines
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Teeth discoloration
Bone growth inhibition Photosensitivity NOT if PG |
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Macrolides
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Acute cholestatic hepatitis
Eosinophilia Increases [ ] of theophyllines and oral anti coag |
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Chloramphenical
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Anemia, aplastic anemia
Grey baby |
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Clindamycin
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Pseudomembranous colitis
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Fluroquinolones
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Damage to cartilage
Tendonitis and rupture in adults Leg cramps and myalgias in kids NOT if PG or kid |
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Metronidazole
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Rxn w/ alcohol
Metallic taste |
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Polymixins
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Acute renal tubular necrosis
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Ethambutol
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Optic neuropathy
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INH
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Neuro, hepato
(B6 to help) Drug induced SLE |
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Rifampin
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Induces P450
Orange body fluids |
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Amphotericin B
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Fever/chills, hypotension
Nephro, arrhythmias Anemia, IV phlebitis |
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Azoles
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Hormone synthesis inhibition
Inhibits P450 |
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Flucytosin
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BM suppression
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Griseofulvin
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Teratogenic, carcinogenic
Induces P450, warfarin metabolism |
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Amantadine
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Ataxia, dizziness
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Ribavirin
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Hemolytic anemia
Severe teratogen |
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Ganciclovir
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Leukopenia, neutropenia
Renal toxicity |
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Foscarnet
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Nephro
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Protease inhibitors
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Hyperglycemia, lipodystrophy
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Reverse transcriptase inhibitors
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BM suppression, lactic acidosis
Megaloblastic anemia (ZDV) |
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NOT if PG
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Sulfonamides, AGs, fluoroquinolones
Erythromycin, metronidazole, tetracyclines Ribavirin, griseofulvin, chloramphenicol (SAFE Moms Take Really Good Care) |
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Hydralazine
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Lupus like syndrome
Tachycardia, fluid retention |
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Minoxidil
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Hypertrichosis, pericardial effusion
Angina |
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CCBs
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Cardiac depression
Peripheral edema Flushing, dizziness, constipation |
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Statins
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Rhabdomyolysis
Reversible + LFTs |
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Niacin
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Red, flushed face
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Cholestyramine (bile acid resins
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Slightly increase TG
Tastes bad, decrease absorption of fat soluble vitamins |
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Digoxin
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Arrhythmia, +PR, -QT
Increased by renal failure, hypoK, and quinidine |
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Class IA
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TDP (quinidine)
SLE like syndrome (procainamide) |
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Class IB
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CV depression
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Class IC
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Proarrhythmic, prolongs refractory period of AV
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Class II
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Impotence, asthma, sedation
Masks hypoglycemia Dyslipidemia (metoprolol) |
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Class III
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TDP (Sotalol)
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Amiodarone (class III)
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Pulm fibrosis, corneal deposits
Hepatotoxicity, skin deposits Constipation, CV effect Hypo/Hyperthyroid |
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Class IV
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Constipation, flushing
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H2 blockers
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Inhibit P450 and antiandrogenic (cimetidine)
Decrase renal excretion of creatinine (cimetidine and ranitidine) |
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Misoprostol
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Diarrhea, abortifacient
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Antacids
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Aluminum - constipation and hypophos
Mg - diarrhea, hyporeflexia, hypotension, cardiac arrest Ca - hyperCa, reboud acid increase |
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Sulfasalazine
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Reversible oligospermia
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Metoclopramide
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Parkinsonian effects
Interaction w/ digoxin and diabetic agents NOT in SI obstruction |
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Heparin
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HIT, drug interations
Protamine sulfate for reversal |
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Warfarin
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Teratogenic, interaction
Skin/tissue necrosis NOT if PG |
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Thrombolytics
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NOT if active bleed, history of intracranial bleeding, recent surgery
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ASA
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Reye's
Tinnitus |
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Methotrexate
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Myelosuppression
Leucovorin rescue |
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5-FU
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Myelosuppression, photsensitivity
Thymidine rescue |
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6-MP
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BM, GI, liver
Increased toxicity w/ allopurinol |
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Cytarabine
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Megaloblastic anemia
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Cyclophsophamide
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Hemorrhagic cystitis (mesna to tx)
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Cisplatin
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Nephro
Acoustic nerve damage |
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Busulfan
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Pulm fibrosis
Hyperpigmentation |
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Doxorubicin
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Cardiotoxicity
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Bleomycin
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Pulm fibrosis
Skin changes Minimal myelosuppression |
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Etoposide
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Alopecia
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Trastuzumab
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Cardiotoxicity
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Imatinib (gleevec)
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Fluid retention
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Vincrist and blastine
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Neuro, paralytic ileus (cristine)
BM suppression (blastine) |
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NSAIDs
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Renal damage, ulcers
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Celecoxib
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Increase risk of thrombosis
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Acetaminophen
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Hepatic necorisis
N acetylcysteine as antidote (regenerates glutathion) |
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Bisphosphonates
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Corrosive esophagitis
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Epinephrine for glaucoma
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Mydriasis, stinging
NOT in closed angle |
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Cholinomimetics for glaucoma
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Miosis, cyclospasm
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Latanoprost for glaucoma
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Darkens color of iris
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Opioid analgesics
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Addiction, respriatory depsression
Constipation, miosis NO tolerance for miosis and constipation Naloxone or naltrexone for OD |
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Tramadol
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Similar to opioids
Decreases seizure threshold |
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Benzodiazepines
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Sedattion
Todlerance Dependence |
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Carbamazepine
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Diplopia
Ataxia, blood dyscrasias Liver toxicity, teratogenesis Induction of P450 |
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Ethosuximide
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Fatigue, HA, urticaria
Steven's Johnson syndrome |
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Phenobarbital
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Sedation, tolerance, dependence
Induction of P450 |
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Phenytoin
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Nystagmus, diplopia, ataxia, sedation
Gingival hyperplasia, hirsutism Megaloblastic anemia, teratogenesis SLE like syndrome Induction of P450 |
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Valproic acid
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Neural tube defects, tremor, weight gain
Rare hepatotoxicity |
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Lamotrigine
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Steven's Johnson syndrome
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gabapentin
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Sedation, ataxia
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Topiramate
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Sedation, mental dulling, kidney stones, weight loss
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L dopa
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Arrhythmias
Dyskinesia after, akinesia between |
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Sumatriptan
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Coronary vasospasm
NOT in CAD or Prinzmetals |
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TCAs
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Convulsions, coma, cardiotoxicity
Confusion and hallucinations for elderly |
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SSRIs
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Serotonin syndrome w/ any drug that increases serotonin
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Venlafaxine
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Increase in BP
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Duloxetine
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Increase in BP
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Mirtazapine
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Sedation, increased appetite, dry mouth
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Maprotiline
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Orthostatic hypotension
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MAO-Is
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HTN crisis w/ tyramine ingestion
NOT w/ SSRIs or meperidine |
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Mannitol
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Pulm edema
NOT in anuria or CHF |
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Acetazolamide
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Hyperchloremic metabolic acidosis
Neuropathy |
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Loop
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Oto, hypoK, dehydration, allergy, nephritis, gout
OH DANG |
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HCTZ
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hyperglycemia, lipidemia, uricemia, calcemia (hyperGLUC)
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ACE-Is
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Cough, angioedema, proteinuria, taste changes, hypotension, PG problems, rash, increased renin, lower ang II, hyperK
CAPTOPRIL NOT in bilateral renal artery stenosis |
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Lispro
Aspart |
Hypoglycemia
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Glyburide
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Hypoglycemia
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Metformin
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Lactic acidosis
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Glitazones
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Weight gain
Edema Hepato and CV toxicity |
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Sibutramine
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HTN
Tachycardia |
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PTU
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Skin rash
Agranulocytosis Aplastic anemia |
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Demeclocycline
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Abn of bone and teeth
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