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14 Cards in this Set
- Front
- Back
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Secreted by macrophages. Causes acute inflammation. Induces chemokine production to recruit leukocytes; activates endothelium to express adhesion molecules. An endogenous pyrogen.
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IL-1
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Secreted by Th1 cells. Stimulates growth of helper and cytotoxic T cells
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IL-2
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Secreted by activated T cells. Supports the growth and differentiation of bone marrow stem cells. Has a function similar to GM-CSF
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IL-3
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Secreted by Th2 cells. Promotes growth of B-cells. Enhances switching to IgE and IgG. Inhibits Th1 Cells
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IL-4
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Secreted by Th2 cells. Promotes differentiation of B-cells. Enhances switching to IgA. Stimulates production and activation of eosinophils
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IL-5
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Secreted by Th cells and macrophages. Stimulates production of acute phase reactants and immunoglobulins
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IL-6
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Secreted by macrophages. Major chemotactic factor for neutrophils.
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IL-8
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Secreted by regulatory T-cells. Inhibits actions of activated T-cells.
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IL-10
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Secreted by B cells and macrophages. Activates NK cells and Th1 cells.
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IL-12
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Secreted by Th1 cells. Stimulates macrophages (inhibits Th2). Think of granulomas
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Gamma-interfeuron
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Secreted by macrophages. mediates septic shock. Causes leukocyte recruitment, vascular leak.
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TNF Alpha
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Used to treat MS. Activates NK Cells
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Interferon Beta
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Used to treat Hep B, Hep C, and Kaposi's sarcoma, leukemias, and malignant melanoma.
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Interferon Alpha
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Used to treat Chronic Granulomatous Disease, also given for IL-12 Deficiency (because it cannot be secreted by Th1 cells, no IL-12 to stimulate)
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Interferon Gamma
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