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17 Cards in this Set
- Front
- Back
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What cytokines are secreted by macrophages?
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IL-1
IL-6 IL-8 IL-12 TNF-α |
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What cytokines are secreted by all T cells?
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IL-2
IL-3 |
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What are secreted by Th1 cells and not Th2?
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IFN-γ (interferion gamma)
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What is secreted by Th2 cells and not Th1?
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IL-4
IL-5 IL-6 IL-10 |
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IL-1
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Secreted by macrophages
Causes fever, acute inflammation Activation of endothelium to express adhesion molecules Induces chemokine secretion to recruit leukocytes Hot T-Bone stEAk |
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IL-6
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Secreted by macrophages and Th2
Causes fever and stimulates production of acute phase proteins (from the liver) |
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IL-8
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Secreted by macrophages
Major chemotactic factor for neutrophils "Clean up on aisle 8" Neutrophils are recruited by IL-8 to clear infecdtions |
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IL-12
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Secreted by macrophages
Induces differentiation of T cells into Th1 cells. Activates NK cells. Also secreted by B cells |
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TNF-α
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Secreted by macrophages
Mediates septic shock. Activates endothelium. Causes leukocyte recruitment. *Vascular leak* Locally, it causes increase movement of WBC to an area, systemically, leads to shock |
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IL-2
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Secreted by all T cells
T-cell stimulator - Stimulates growth of helper, cytotoxic, and regulatory T cells Activates NK cells and monocytes Anti-cancer (metastatic melanoma, RCC) "Hot T-Bone stEAk" |
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IL-3
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Secreted by all T cells
Supports the growth and differentiation of bone marrow stem cells Functions like GM-CSF (which increases neutrophil counts) |
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IFN-γ
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Secreted by Th1 cells
Macrophage stimulator - Activates macrophages and Th1 cells (auto). Suppresses Th2 cells. Has antiviral and antitumoral properties |
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IL-4
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Secreted by Th2 cells
Induces differentiation into Th2 cells. B-cell stimulator - Promotes growth of B cells. Enhances class switching to IgE and IgG "Hot T-Bone stEAk" |
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IL-5
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Secreted by Th2 cells
B-cell stimulatory - Promotes the differentiation of B cells. Enhances class switching to IgA. Stimulates growth and differentiation of eosinophils "Hot T-Bone stEAk" |
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IL-10
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Secreted by Th2 cells
Modulates inflammatory response. T-cell and macrophage inhibitor - Inhibits actions of activated T cells and Th2. (similar to TGF-beta, anti-inflammation) Also secreted by regulatory T cells |
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Secreted by virally infected cells
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IFN alpha, beta
Warn neighbors |
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Neutrophil recruiters
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C5a
IL-8 LTB4 Kallikrein |
