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22 Cards in this Set
- Front
- Back
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IL-1 Secreted by
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Macrophages
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IL-1 Function
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-Acute Inflammation
-Induces chemokine production to recruit leukocytes -Activates endothelium to express adhesion molecules -Endogenous PYROGEN |
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IL-2 Secreted by
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Th Cells
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IL-2 Function
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Stimulates growth of Helper and Cytotoxic T Cells
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IL-3 Secreted by
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Activated T cells
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IL-3 Function
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Supports growth and differentiation of bone marrow stem cells
**Function is similar to GM-CSF** |
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IL-4 Secreted by
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Th-2 Cells
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IL-4 Function
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-Promotes growth of B Cells
-Class switching to IgE and IgG |
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IL-5 Secreted by
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Th-2 Cells
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IL-5 Function
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-Promotes differentiation of B Cells
-Class switching to IgA -Stimulates production and activation of Eosiniophils |
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IL-6 Secreted by
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-Th Cells
-Macrophages |
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IL-6 Function
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-Stimulates production of acute phase reactants
-Stimulates production of immunoglobulins |
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IL-8 Secreted by
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Macrophages
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IL-8 Function
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Major Chemotactic factor for Neutrophils
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IL-10 Secreted by
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Regulatory T Cells
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IL-10 Function
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-Inhibits actions of activated T cells
-Activates Th-2 -Inhibits Th-1 |
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IL-12 Secreted by
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-B cells
-Macrophages |
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IL-12 Function
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-Activates NK cells
-Activates Th-1 cells (Stimulates naive Th cells to produce Th-1 class memory cells) |
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INF-Gamma Secreted by
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Th-1 Cells
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INF-Gamma Function
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-Stimulates Macrophages
-Activates Th-1 -Inhibits Th-2 |
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TNF Secreted by
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Macrophages
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TNF Function
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-Mediates Septic Shock
-Leukocyte Recruitment -Vascular Leak |
