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22 Cards in this Set
- Front
- Back
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Azathioprine
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Inhibit nucleotide biosynthesis
Salvage pathway inhibitor Antiproliferative |
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Methotrexate
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Inhibit nucleotide biosynthesis
Inhibits DHFR for purine synthesis Antiproliferative |
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Cyclophosphamide
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Alkylates DNA
Double-stranded breaks Elimination is independent of kidney Antiproliferative |
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Mycophenylate
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Inhibits purine biosynthesis
Inhibits IMP to GMP conversion Antiproliferative |
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Leflunomide
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Inhibits pyrimidine biosynthesis
Long half-life Antiproliferative |
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Cyclosporin
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Blocks calcineurin --> NFAT activation
Blocks T cell activation |
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FK506
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Blocks T cell activation via FK506bp
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Rapamycin
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Blocks T cell G1-S transition
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Infliximab
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Anti-TNF
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Adalamab
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Anti-TNF
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Entanercept
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Anti-TNF
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Natalizumab
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VLA-4 antibody
Used to treat MS |
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Cortisol
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Glucocorticoid
Weak anti-inflammatory High salt retention Short duration |
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Prednisone
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Glucocorticoid
Moderate anti-inflammatory Moderate salt retention Moderate duration |
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Prednisolone
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Glucocorticoid
Moderate anti-inflammatory Moderate salt retention Moderate duration |
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Triamcinolone
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Glucocorticoid
Moderate anti-inflammatory No salt retention Moderate duration |
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Dexamethosone
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Glucocorticoid
Strong anti-inflammatory No salt retention Long duration of action |
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Aspirin
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COX inhibitor
Gastric bleeding |
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Acetaminophen
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Analgesic
Antipyretic No gastric bleeding |
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Ibuprofen
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COX inhibitor
Some gastric bleeding Renal and liver effects |
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Naproxen
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COX inhibitor
Some gastric bleeding Longer duration of action than ibuprofen |
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Celebrexx
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COX-2 inhibitor
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