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22 Cards in this Set
- Front
- Back
Azathioprine
|
Inhibit nucleotide biosynthesis
Salvage pathway inhibitor Antiproliferative |
|
Methotrexate
|
Inhibit nucleotide biosynthesis
Inhibits DHFR for purine synthesis Antiproliferative |
|
Cyclophosphamide
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Alkylates DNA
Double-stranded breaks Elimination is independent of kidney Antiproliferative |
|
Mycophenylate
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Inhibits purine biosynthesis
Inhibits IMP to GMP conversion Antiproliferative |
|
Leflunomide
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Inhibits pyrimidine biosynthesis
Long half-life Antiproliferative |
|
Cyclosporin
|
Blocks calcineurin --> NFAT activation
Blocks T cell activation |
|
FK506
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Blocks T cell activation via FK506bp
|
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Rapamycin
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Blocks T cell G1-S transition
|
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Infliximab
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Anti-TNF
|
|
Adalamab
|
Anti-TNF
|
|
Entanercept
|
Anti-TNF
|
|
Natalizumab
|
VLA-4 antibody
Used to treat MS |
|
Cortisol
|
Glucocorticoid
Weak anti-inflammatory High salt retention Short duration |
|
Prednisone
|
Glucocorticoid
Moderate anti-inflammatory Moderate salt retention Moderate duration |
|
Prednisolone
|
Glucocorticoid
Moderate anti-inflammatory Moderate salt retention Moderate duration |
|
Triamcinolone
|
Glucocorticoid
Moderate anti-inflammatory No salt retention Moderate duration |
|
Dexamethosone
|
Glucocorticoid
Strong anti-inflammatory No salt retention Long duration of action |
|
Aspirin
|
COX inhibitor
Gastric bleeding |
|
Acetaminophen
|
Analgesic
Antipyretic No gastric bleeding |
|
Ibuprofen
|
COX inhibitor
Some gastric bleeding Renal and liver effects |
|
Naproxen
|
COX inhibitor
Some gastric bleeding Longer duration of action than ibuprofen |
|
Celebrexx
|
COX-2 inhibitor
|