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14 Cards in this Set

  • Front
  • Back
anti lymphocyte globulins and their SE
ATGAM and Thymoglobulin (complement lysis of T cells)

SE: CRS, serum sickness, leukopenia, thrombocytopenia
Alemtuzumab
Ab against CD52
Induction agent

Injection site reactions, anemia, thrombocytopenia, neutropenia
Basiliximab
IL-2R antagonist prevents activation

Abdominal pain, dizziness, insomnia
Methylprednisone
Corticosteroid

Blocks cytokine gene expression decreasing immune response

HTN, hyperglycemia, mood, fluid retention, impaired wound healing.
5 Induction Agents
ATGAM
Thymoglobulin
Alemtuzumab
Basiliximab
Methylprednisone
7 Immunosuppressive maintenance Agents
Tacrolimus, Cyclosporine
Mycophenolate, Azathioprine
Sirolimus, everolimus
Prednisone
4 classes of immunosuppressive maintenence agents
Calcineurin inhibitors
antiMetabolites
mTOR inhibitors
Corticosteroids
Tacrolimus,
Calcineurin inhibitors inhibit IL-2 synthesis
Hyperglycemia
nephrotoxicity, neurotoxicity
alopecia, hyperkalemia
Cyclosporine
calcineurin INH
HTN, nephrotox
gingival hyperplasia, hirsutism
Mycophenolate Mofetil or Sodium
prevents RNA/DNA synth, inhibits proliferation of T and B cells

GI intolerance, BM suppression
Azathioprine
Mycophenolates
antimetabolite, prevents RNA/DNA synthesis inhibiting T/B cell proliferation
GI intolerance, BM suppression
Sirolimus
Everolimus
MOA
binds FKBP-12 inhibiting rapamycin targent inhibiting proliferation of T and B cells
Sirolimus
Everolimus MOA
Anemia, impaired wound healing, proteinuria, hyperlipidemia
EV: mouth ulcers, renal artery thrombosis
SI: heptatic artery thrombosis
Prednisone
blocks cytokinne gene expression
GERD, Hyperglycemia, HTN, osteoporosis, chronic adrenal insufficiency