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14 Cards in this Set
- Front
- Back
anti lymphocyte globulins and their SE
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ATGAM and Thymoglobulin (complement lysis of T cells)
SE: CRS, serum sickness, leukopenia, thrombocytopenia |
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Alemtuzumab
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Ab against CD52
Induction agent Injection site reactions, anemia, thrombocytopenia, neutropenia |
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Basiliximab
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IL-2R antagonist prevents activation
Abdominal pain, dizziness, insomnia |
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Methylprednisone
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Corticosteroid
Blocks cytokine gene expression decreasing immune response HTN, hyperglycemia, mood, fluid retention, impaired wound healing. |
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5 Induction Agents
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ATGAM
Thymoglobulin Alemtuzumab Basiliximab Methylprednisone |
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7 Immunosuppressive maintenance Agents
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Tacrolimus, Cyclosporine
Mycophenolate, Azathioprine Sirolimus, everolimus Prednisone |
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4 classes of immunosuppressive maintenence agents
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Calcineurin inhibitors
antiMetabolites mTOR inhibitors Corticosteroids |
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Tacrolimus,
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Calcineurin inhibitors inhibit IL-2 synthesis
Hyperglycemia nephrotoxicity, neurotoxicity alopecia, hyperkalemia |
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Cyclosporine
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calcineurin INH
HTN, nephrotox gingival hyperplasia, hirsutism |
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Mycophenolate Mofetil or Sodium
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prevents RNA/DNA synth, inhibits proliferation of T and B cells
GI intolerance, BM suppression |
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Azathioprine
Mycophenolates |
antimetabolite, prevents RNA/DNA synthesis inhibiting T/B cell proliferation
GI intolerance, BM suppression |
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Sirolimus
Everolimus MOA |
binds FKBP-12 inhibiting rapamycin targent inhibiting proliferation of T and B cells
|
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Sirolimus
Everolimus MOA |
Anemia, impaired wound healing, proteinuria, hyperlipidemia
EV: mouth ulcers, renal artery thrombosis SI: heptatic artery thrombosis |
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Prednisone
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blocks cytokinne gene expression
GERD, Hyperglycemia, HTN, osteoporosis, chronic adrenal insufficiency |