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20 Cards in this Set
- Front
- Back
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General and common regimen
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Start treatment before transplant
common regimen= cyclosporine + prednisolone + azathlaprine (or monoclonal antibody) AD: viral, fungal, bacterial infections and lymphomas |
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Cyclosporine
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binds with cyclophelin to inhibit calcineurin which stop IL-2,IL-3, IFN-γ
- No T-cell activation used in combo with steroids, cytotoxic agents, and mycophenolate U: psoriasis, atopic dermatitis, RA, keratoconjunctivitis sicca, ulcerative colitis AD: gum hyperplasia, hyperglycemia, peripheral neuropathy, pruritis, hyperkalemia, nephro/hepatotoxicity, gall stones, infections cyclosporine G has less nephrotoxicity than cyclosporine A |
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Tarcolimus
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inhibits calcineurin directly
- no T cell activation via IL-2,3, IFN-γ |
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Azathioprine
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inhibits purine synthesis
- no proliferation of leukocytes Pro-drug: converted to 6-mercaptopurine and 6-thioinosinic a. U: immunosuppressant, Pa, crohn's, ulcerative colitis AD: GI mucositis, infection, if used with allopurinol, the enzyme TPMT deactivates 6-mercaptopurine, CARCINOGEN, pregnancy |
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Methotrexate
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inhibitor of dihydrofolate reductase
U: immunosupressant, RA, psoriasis, Cancer of breast, lungs,ovary, bladder and neck AD: myelosuppression, GI, hemorrhagic enteritis, neurotoxicity, hepatotoxicity |
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RH₀(D)
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U: prevent hemolytic disease of newborn
Given 72 hrs before delivery |
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infliximab
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inhibits TNF-α
U: RA, crohn's |
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Abciximab
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inhibits GP IIa/IIIb receptor on platelets
U: no coagulation in coronary angiography |
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Rituximab
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targets phosphoprotein on CD20 on B-lymphocytes
U: non-hodgkin's |
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Daclizumab, Basiliximab
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inhibits IL-2 on activated T cells
U: acute rejection of kidney |
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Palivizumab
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inhibits RSV protein
U: RSV infections |
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Etanercept
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Contains TNF receptor
U: RA |
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IL-2 (Aldesleukin)
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promotes differentiation of lymphocytes and NKs
U: renal cell carcinoma and metastatic melanoma |
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IL-11
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(+) platelet function
U: for thrombycytopenia |
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G-CSF (filgrastim)
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proliferation and differentiation of granulocytes
U: neutropenia |
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GM-CSF
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stimulates granulocytes and macrophages
U: marrow recovery after transplant and AML |
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EPO
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(+) RBC
U: anemia |
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IFN-alpha
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JAK-STAT
U: melanoma, leukemia, kaposis, Hep B/C |
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IFN-β
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anti-infammatory
U: improves integrity of blood brain barrier in multiple sclerosis |
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IFN-γ
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macrophage activating factor, (+) TNF
U: chronic granulomatous disease. |
