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18 Cards in this Set
- Front
- Back
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What drug inhibits differentiation and activation of T cells by inhibiting calcineurin?
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cyclosporine
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Nephrotox, peripheral neuropathy, hypertension, pleural effusions and hyperglycemia are associated with what drug?
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Tacrolimus (FK506)
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What do you give to prevent nephrotox with cyclosporine use?
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mannitol diuresis
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What drug binds to FK-binding protein and what does it inhibit?
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Tacrolimus
inhibits secretion of IL-2 and other cytokines |
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What drug should you not give with AZA?
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allopurinol
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What drugs are used specifically for kidney transplants?
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AZA, muromonab-CD3(OKT3), Sirolimus (rapamycin)
all the drugs are used for solid organ transplant but these three have kidney specifically listed |
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Daclizumab is a monoclonal ab against what?
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IL-2 receptors on activated T cells
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Mycophenolate mofetil blocks lymphocyte proliferation by:
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inhibiting de novo gaunine synthesis
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Binds to mTOR and inhibits T cell proliferation in reponse to IL-2
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Sirolimus (rapamycin)
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Side effects include cytokine release syndrome, hypersensitivity rx
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Muromonab-CD3 (OKT3)
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What drug predisposes to viral infections, lymphomas, and nephrotoxicity?
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Cyclosporine
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What drug causes bone marrow suppression?
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AZA
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What drugs are used for autoimmune disorders (2)?
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AZA & cyclosporine
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What drug blocks cellular interaction with CD3 protein reponsible for T cell signal?
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Muromonam-CD3 (OKT3)
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This drug interferes with metabolism & synthesis of nucleic acids
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AZA
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this drug binds to cyclophilins
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cyclosporin
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this drug causes hyperlipidemia, t-penia, leukopenia
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sirolimus
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this drug is used in combo with cyclosporine & corticosteroids
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sirolimus
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