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6 Cards in this Set

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Immunosuppressants general
indications - transplants, severe rheumatoid arthritis, other imflamatory diseases

how it works: glucocorticoids, antimetabolites: inhibit lymphocyte replication, antibodies, calcineurin inhibitors: disrupt T-cell function
Immunosuppresants contraindications
- leukemia
- metastatic cancer
- active infection
- renal or liver disease
- pregnancy
Immunosupressants nursing interventions
- nephrotoxicity (micro calcifications & interstitial fibrosis)
- risk for liver toxicity
- monitor for infection
- possible hypertension (monitor T, BP)
- hirsutism, leukopenia, gigival hyperplasia, gynecomastia, sinusitus, kyperkalemia
- NO grapefruit juice
- possible weight gain
cyclophosphamide
Antimetabolite immunosuppresant

Imuran

PO; 3-5 mg/kg/day intitially
IV; ditto
may be able to reduce to 1-3 mg/kg/day
cyclosporine
Calcineurine inhibitor immunosuppresant

Sandimmune, Neoral

PO; 250 mg q12h for 2 wk
may increase to 500mg q12h
(max 1g/d)
lymphocyte immune globulin
Antibody immunosuppresant

Antithymocyte Globulin

IV;10-30 mg/kg/d