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6 Cards in this Set
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Immunosuppressants general
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indications - transplants, severe rheumatoid arthritis, other imflamatory diseases
how it works: glucocorticoids, antimetabolites: inhibit lymphocyte replication, antibodies, calcineurin inhibitors: disrupt T-cell function |
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Immunosuppresants contraindications
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- leukemia
- metastatic cancer - active infection - renal or liver disease - pregnancy |
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Immunosupressants nursing interventions
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- nephrotoxicity (micro calcifications & interstitial fibrosis)
- risk for liver toxicity - monitor for infection - possible hypertension (monitor T, BP) - hirsutism, leukopenia, gigival hyperplasia, gynecomastia, sinusitus, kyperkalemia - NO grapefruit juice - possible weight gain |
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cyclophosphamide
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Antimetabolite immunosuppresant
Imuran PO; 3-5 mg/kg/day intitially IV; ditto may be able to reduce to 1-3 mg/kg/day |
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cyclosporine
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Calcineurine inhibitor immunosuppresant
Sandimmune, Neoral PO; 250 mg q12h for 2 wk may increase to 500mg q12h (max 1g/d) |
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lymphocyte immune globulin
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Antibody immunosuppresant
Antithymocyte Globulin IV;10-30 mg/kg/d |
