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41 Cards in this Set
- Front
- Back
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usual target of transplant rxn?
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organ vasculature
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what is a haplotype?
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combo of several alleles in a gene cluster
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we each get how many hla haplotypes from our parents?
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2
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hla haplotypes from parents are expressed how?
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codominantly
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if ab sees foreign ag from graft tissue and binds, what happens?
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complement activation or adcc
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hyperacute rejection time? acute?
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minutes to hours; days to weeks
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which antigens are an example of hyperacute rejection?
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abo and hla
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acute rejection scenarios (3):
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1. t cells in recipient see foreign ag, immune response
2. apc from graft enters blood and presents antigens to t cells in lymph tissue 3. mhc from graft taken by recipients apc to lymp |
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most immunosupp drugs aimed at what rejection scenario?
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acute-mhc from graft taken by recipient apc to lymph tissue
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how does indirect coomb's work?
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recipient serum w/ donor rbc to check agglut.
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ways to check for tissue compati?
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serological tissue typing, cross match, genotyping
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what is serological tissue typing?
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standard ab. to detect which hla the donor and recipient have
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cross match checks what?
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recipient doesn't have ab to donor tissue
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how do cyclosporin, sirolimus, and tacromilus work?
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cyclosporin-blocks t cell cytokin production; sirolumus-inhibits t cell activation and proliferation and inhibits ab formation; tacrolimus-same as cyclosporin
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how does azathioprine work?
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blocks prolif of lymph precurs
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how does mycophenolate work?
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blocks lymp prolif by inhibiting guanine nucleotide synt
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how does rapamycin work?
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blocks lymph prolif by inhibiting il-2 signal
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how do steroids work?
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reduce inflam by inhibit macrophage cytokine secretion
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how does anticd3 work?
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depletes t cells
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how does anti-il2 receptor ab work?
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inhibits t cell prolif
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how does ctla4 work?
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inhibits t cell activaiton by blocking b7 costimulator binding to cd28
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anticd3 may work which way?
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may just inhibit t cell activation or may activate t cells and lead to death inappropriately
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gvhd can start where?
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lungs, gut, liver, skin
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gvhd starts when?
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7-30 dyas
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once it has begun why is there high mortality in gvhd?
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resp problems and infection
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bm transplant indicated in what disease?
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immunodef where you need to replace all of immune system
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what antigen is used to id and pull out hematopoetic stem cells?
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cd-34
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what is cd34?
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early progenitor cell which diff. into hemato stem cells
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th1 or th2 in pregnant t cell response?
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th2
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mhc i increase or decrease on trophoblast?
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decrease
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how does ctla4 work?
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inhibits t cell activaiton by blocking b7 costimulator binding to cd28
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anticd3 may work which way?
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may just inhibit t cell activation or may activate t cells and lead to death inappropriately
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gvhd can start where?
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lungs, gut, liver, skin
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gvhd starts when?
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7-30 dyas
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once it has begun why is there high mortality in gvhd?
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resp problems and infection
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bm transplant indicated in what disease?
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immunodef where you need to replace all of immune system
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what antigen is used to id and pull out hematopoetic stem cells?
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cd-34
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what is cd34?
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early progenitor cell which diff. into hemato stem cells
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th1 or th2 in pregnant t cell response?
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th2
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mhc i increase or decrease on trophoblast?
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decrease
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hla-g expression on trophoblast high or low?
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high
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