Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
The Wheal of a wheal-and-flare skin reaction
a)occurs 24-27 hours post-injection b)is caused by edema resuliting from the histamine-induced capillary permeability c)is caused by vasodilation and increased blood flow d)can be induced by haptens e) is only scored positive if it is larger than 15mm in diameter |
B
|
|
|
How long does wheal take to occur
|
occurs in 1-15 min post injection
|
|
|
What is flare?
|
vasodilation and increased blood flow
|
|
|
What is valency?
|
the idea that for haptens you need to have multivalency to cause a reaction
|
|
|
What is a RAST test
|
Measures amount of IgE there is for an antigen/allergen
|
|
|
Skin test
|
measures the in vivo response to the allergen
can't tell exactly what is causing the response |
|
|
Can RAST measure allergic responses to ragweed?
|
it can, but it is not just for ragweed
|
|
|
What inhibits degranulation and histamine?
|
Cromolyn sodium
|
|
|
How does cromolyn sodium stop degranulation of mast cells?
|
stabilization of the membrane
|
|
|
is cromolyn sodium effective after an allergic response?
|
No! Histamine has already been released
|
|
|
How do anti histamines work?
|
antihistamines bind to histamine-binding sites on smooth muscle and competitively inhibit the binding and subsequent pharmacologic action of histamine
|
|
|
What is the major difference between asthma and allergic rhinitis ?
|
asthma affects the mid sized airways of the lower respiratory tract, whereas allergic rhinitis affects only the upper respiratory tract
|
|
|
How does a blocking anti-body work?
|
You use a different Ab to bind the allergen, preventing IgE from binding and causing a rxn
|
|
|
Basophils and Mast Cells are similar in what way
|
they both have receptors on their surfaces that bind the Fc region of the IgE (FcERI)
|
|
|
What must IgE be bound to before encountering an allergen in order to lead to the release of histamine?
|
the FcERI on mast cells
|
|
|
if an allergen bound to an IgE that was not already bound to a mast cell, what would happen?
|
you would have no release of histamine
|
|
|
What is the function of corticosteroids?
|
steriods decrease T-Cell and neutrophil activation and inhibit cytokine production
|
|
|
What stabilzes the mast cell macrophages
|
chromalyn sodium
|
