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23 Cards in this Set
- Front
- Back
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Optimal site of antigen administration to elicit an immune response
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Subcutaneous or intramuscular
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Properties of antigens that contribute to immunogenicity
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Large, complex, particulate and foreign
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Agents that improve immunogenicity when administered with an antigen
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Adjuvants
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Slow release of Ag; enhance Ag processing; stimulate innate immunity
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Mechanism of action of adjuvants
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Small molecule that can not induce an immune response
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Hapten
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Conjugate or complex that induces an immune response to a hapten
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Hapten-carrier complex
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Antibody that reacts with a single epitope
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Monoclonal antibody
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Plasma cell fused to malignant myeloma cell
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Hybridoma
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Pool of antibodies directed against multiple epitopes
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Polyclonal antibody
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Strength of interaction between one antibody and its antigen
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Affinity
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Sum of the strengths of multivalent antigens with all of the antibodies that bind to that antigen
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Avidity
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Reaction of an antibody with a cell or particle
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Agglutination
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Agglutination reaction of red blood cells with antibody
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Hemagglutination
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Hemagglutination test used to detect the presence of anti-Rh antibodies
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Coomb’s test
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Killing of a cell with antibody in presence of complement
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Lysis
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Inactivation of toxin or block of infectivity of a virus
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Neutralization
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Aggregation of an insoluble particle by an antibody
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Flocculation
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Concentration of antibody in a serum sample
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Titer
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Binding assay that uses light scatter to measure concentration of Ig in serum
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Nephelometry
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Binding assay that measures concentration of antibody or antigen in solution (plasma or serum)
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ELISA
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Binding assay that measures presence of proteins (antigens) in tissues or solutions
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Western blot
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Binding assay that detects presence of antigen on a slide using fluorescent-tagged antibodies
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Fluorescent Microscopy
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Binding assay that uses fluorescent-tagged antibodies and laser beam deflection to quantify cell populations.
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Flow cytometry
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