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21 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Mechanism and use of sodium cromoglycate?
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Blocks mast cell degranulation. Used to treat type I hypersensitivity.
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Mechanism and use of omalizumab?
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Anti-IgE monoclonal antibody that binds the Fc portion of IgE to block it from binding to the Fce receptor.
Used to treat type I hypersensitivity. |
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Mechanism and use of Amantadine HCl?
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Blocks viral penetration and uncoating (M2 protein) , buffers pH of endosome, causes release of dopamine from intact nerve terminals.
Used for prophylaxis and treatment of Influenza A, Rubella, Parkinson's disease Note: 90% of all Influenza A strains are resistant, so it is not used. "A man to dine takes off his coat" |
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Toxicity of Amantadine?
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Ataxia, dizziness, slurred speech
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Mechanism and use of Rimantadine?
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Inhibits influenza viral replication. Used to treat (and sometimes prevent) influenza. Can shorten duration and moderate severity.
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Mechanism and use of Zanamivir?
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Neuroaminidase inhibitor on the influenza virus, which prevents it from budding from its host cell and infecting other cells.
Used in the treatment of influenza types A and B. |
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Mechanism and use of Oseltamivir?
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Neuroaminidase inhibitor on the influenza virus, which prevents it from budding from its host cell and infecting other cells.
Used in the treatment and PROPHYLAXIS of influenza types A and B. Tradename? |
Tamiflu
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Mechanism and use for the Flu Shot?
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Killed influenza virus that is injected to produce an innate immune response against the killed virus.
Used to vaccinate against influenza |
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Mechanism and use of FluMist?
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Live attenuated influenza vaccine that is a nasal spray. This produces a weak immune response to the attenuated virus.
Cons of FluMist for influenza vaccination? |
Less effective and shorter duration of immunity (because it does not elicit as large of an immune response). Also there is a risk of the virus reactivating.
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Mechanism and use of Rituximab?
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Monoclonal antibody that targets CD20 on B cells that are cancerous or auto-reactive.
Used for non-Hodkgin lymphoma, CLL, rheumatoid arthritis |
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Mechanism and use of Cyclosporin A?
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Blocks the transcription of IL2 to suppress T cell activation and proliferation. Used to suppress the immune system (organ transplantation, autoimmune disease)
Side effects? |
Renal Toxicity
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Mechanism and use of Tacrolimus?
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Blocks the transcription of IL2 to suppress T cell activation and proliferation. Used to suppress the immune system (organ transplantation, autoimmune disease)
What is another name for this drug? Side effects? |
aka FK506
Causes renal toxicity |
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Mechanism and use of Ribavirin?
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Inhibits the synthesis of guanine nucleotides by competitively inhibiting IMP dehydrogenase.
Used for RSV and chronic Hepatitis C Toxcities? |
Hemolytic anemia, severe TERATOGEN!
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Mechanism and use of Acyclovir?
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Monophosphorylated by HSV and VZV thymidine kinase. Guanosine analog. Triphosphate formed by cellular enzymes. Preferentially inhibits viral DNA polymerase by chain termination.
Used for HSV mucosal and genital lesions, VZV (not zoster), EBV, prophylaxis in immunocompromised patients Toxicities? |
Generally well tolerated
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Mechanism and use of Famciclovir?
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Similar to acyclovir-- preferentially inhibits viral DNA polymerase by chain termination.
Used in herpes zoster. |
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Mechanism and use of Ganciclovir?
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5'-monophosphate formed by a CMV viral kinase of HSV/VZV thymidine kinase. Guanosine analog. Triphosphate formed by cellular kinases. Preferentially inhibits viral DNA Polymerase.
Used in CMV (especially in immunocompromised patients) Toxicity? |
Leukopenia, neutropenia, thrombocytopenia, renal toxicity
*More toxic to host enzymes than acyclovir |
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Mechanism and use of Infliximab?
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Anti-TNFa biological
Used for autoimmune diseases Side effects? |
Susceptible to infections, development of malignancies
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Mechanism and use of Etanercept?
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Anti-TNFa biological
Used for autoimmune diseases Side effects? |
Susceptible to infections, development of malignancies
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Mechanism and use of Adalimumab?
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Anti-TNFa biological
Used for autoimmune diseases Side effects? |
Susceptible to infections, development of malignancies
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Mechanism and use of IVIG?
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Glycans bind to lectin on myeloid regulatory cells to suppress inflammation and decrease antigen presentation, which in turn decreases T cell responses
Often administered to patients with positive autoimmune disease results Side effects? |
Potential to develop immune complexes
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Mechanism and use of Foscarnet?
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Used against acyclovir resistant HSV
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