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16 Cards in this Set
- Front
- Back
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NFkB
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preformed transcription factor in many immune cells
-inflammatory cytokines, chemokines/receptors, adhesion, complement, growth factors |
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Mannose-binding lectin (MBL)
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On macros/neutros.
-Binds mannose/fucose on some microbes -activates complement cascade, opsonization |
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Natural antibodies
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IgM in plasma. no hypermutation
-produced constitutively by B1 B cells since birth -responsible for blood transfusion rejections -Only recognize polysaccharides and lipids |
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NADPH oxidase
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makes ROS for macros/neutros lysosomal attack
-active only when activated |
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Perforin/granzymes
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NK cells
-perforin forms pore, granzymes enter to induce apoptosis |
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TAP
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Takes processed protein antigens into ER to bind to MHC-I
-assoicated w/ calnexin chaperones |
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Calnexin
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chaperones MHCI alpha-beta2 complex until antigen binds in ER and transported to cell membrane
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Invariant chain
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binds to MHC II until loading into transport vesicles
-transport vesicle cleaves IC and replaces it w/ antigen peptide -covers antigen binding site until antigen arrives |
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FAS/FAS ligand
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expressed in activated lymphocytes
-binding causes apoptosis--self-limiting -mutations show hyperproliferation of lymphocytes (splenomegaly, large lymph nodes, immune complex disease) |
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NFAT
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TF that is translocated into nucleus to induce IL-2 (T cell prolif)
-blocking by cyclosporine, FK506 both prevent T cell proliferation |
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Peroxidase, collagenase
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ECM remodeling
-released by eosinophils in response to allergy/IgE Fc binding |
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MBP
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Major basic protein
-released by eosinophils -parasite toxicity, histamine release activation |
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Neurotoxin
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Released by eosinophils in response to allergic reaction. Anti-parasitic
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Zap-70
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on T cells and NK cells
-bound to CD3 -phosphorylates LAT for downstream signaling after Antigen binding |
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I-kappa-B
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Inhibits NFkB in unstimulated cells.
-phosphorylation of IkB signals activation of NFkB -mediated by IkB kinase |
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Stat-1
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involved in signaling through IFN-receptors
-found in APCs, CD8's, B cells |
