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19 Cards in this Set
- Front
- Back
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What are the general characteristics of innate immunity?
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Basic resistance
in place before antigen is encountered rapid response this uses the SAME response every time no memory generated |
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What are the mechanisms of innate immunity?
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barriers, chemical defenses
cells: macrophages/neutrophils/basophils/eosinophils/mast cells/ NK cells compliment, inflammation, cytokines |
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How do defensins work? what immune system are they part of?
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these are part of the innate immune system.
these are small peptides that work to create pores in microbial membranes |
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Where are alpha defensins found?
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in the small intestine, associated with neutrophils, and NK cells
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where are beta defensins found?
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on most epithelial surfaces
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What are the things that the innate immune system responds to?
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these respond to general factors:
lipopolysaccharide (LPS) N-formyl methionyl Mannose |
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What receptor responds to LPS? what happens?
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this binds to the Toll-like receptor.
results in the production of ROS and killing of microbe |
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What happens when the mannose receptor binds?
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leads to ROS production/phagocytosis
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What does n-formyl methionyl bind to? (receptor)...what happens then?
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this binds "seven alpha helical trans-membrane receptors"
this results in the cell migrating into the tissues |
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What do our innate cells use to recognize foregin cells?
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these use Pattern recognition receptors
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What cells are used in adaptive immunity?
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B and T cells- which are activated by a specific antigen
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How many antigens are TCR's and BCR's able to bind?
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these are specific to only one antigen
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how are TCR's and BCR's created to provide diversity?
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these are created by somatic recombination of gene segments- provides lots of diversity
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What is immunologic memory?
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this is an increase in response time of the adaptive immune system, to reexposure of an antigen
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What mediates Humoral immunity?
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this is mediated by antibodies
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What mediates Cell-mediated immunity?
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this is mediated by T-lymphocytes
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What subtype of adaptive immunity can be transferred with serum?
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Only humoral (antibody) can be transferred via serum
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What does humoral immunity most important in defense against?
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antibodies are used mostly in the defense against:
extracellular microbes, bacteria-fungi-viruses-microbial toxins |
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what does cell mediated immunity mostly target?
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intracellular microbes: mycobacteria, fungi, viruses, tumor cells
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