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47 Cards in this Set
- Front
- Back
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what is immunotherapy?
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this is modulating the immune system to achieve a prophylactic or therapeutic goal.
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What is the name of the anticancer drug using IL-2? what does it do?
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Porleukin
this enhances cell mediated immunitiy, especially T-lymphocytes and NKs |
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How does INF-alpha treat diseases?
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this inhibits viral repilcation
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What is the name for G-CSF's brand name? What does it do?
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Neupogen
this is used to treat neutropenia from a variety of sources |
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What is the name of GM-CSF brand name? what does it do?
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Leukine
this is used to treat neutropenia from a variety of sources |
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What is the brand name of INF-B? what does it do?
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Avonex, Betaseron, Rebif
treats Inflammatory diseases! (helps fight viral infections) |
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What is the brand name of INF-gamma? what does it do?
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Actimmune
this promotes macrophage activation, helps treat chronic granulomatous disease |
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What is the brand name of TNFa blocker? what does it do?
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Enbrel
this blocks the proinflammitory effects of TNFa treats arthritis |
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How does adoptive cellular immunotherapy work?
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this cultures immune cells from a host that have anti-tumor effects.
take from host, activate with IL-2 (Proleukin) then put back in body |
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What are LAK cells and TIL cells? where does each come from?
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LAK- lymphokine activated killer cells- from blood
TIL- tumor infiltrating lymphocytes- from tumor infiltrate |
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What are monoclonal antibodies?
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these are a antibodies from a single immortalized clone of B cells with a SINGLE antigen specificity
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what are polyclonal antibodies?
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variety of B cell clones that work on same antigen, but not same epitope
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What is the HAMA response?
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this is a bad immune response to murine antibodies
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What are Murine antibodies? nomeclature?
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these have No human component
indicated by an O followed by mab. |
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What is the brand name for muromOnab? what does it treat? and where does it come from?
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this is OKT3
it is a CD-3 binding antibody- this is part of T cell receptor, so blocking it acts as an immunosuppresent and mouse origin (as indicated O-mab) |
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What are chimeric antibodies?
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these are anitbodies with murine (non human) antigen binding fragments, and human constant regions
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What is the brand name for infliximab? what does it do? where does it come from?
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this is Remicade
comes from a chimera as indicated by the XI in the name. This binds to TNFa and is used to prevent inflammation processes. (similar to Enbrel) |
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What are humanized antibodies?
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these are 95% human, with murine Complementary Determining Regions
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What is the brand name of Trastuzumab? what does it do? where does it come from?
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Herceptin
Binds HER2/neu protein in breast cancer cells- prevents GF receptor over expression this is 95% human (as indicated by the ZA before MAB) |
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What is the brand name of Adalimumab? where does it come from? what does it do?
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this is Humira
this is a fully human antibody, but generated in transgenic mice binds to TNF-s dampens inflammatory responses for autoimmune diseases |
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What is the brand name of Catumaxomab? what makes it? what does it do?
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Removab
this is a trifuncational mouse produced antibody. BINDS-CD3, EpCAM, and FcR's on cells...used for cancer |
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What is the brand name of Blinatumomab? what makes it? what does it do?
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MT103
this is a bispecific T-cell engager. made by mouse antibodies binds CD3 and CD19 used for non hodgkins lymphoma, and acute lymphoblastic leukemia |
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What do immunoconjugates do? what are these?
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these deliver drugs to cells directly.
they are antibodies bound to radioactive junk, toxins, or chemotherapy drugs |
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What is used to treat digoxin poisoning? what kind of drug is this?
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Digibind-
this is a polyclonal antigioxin FAB fragment, made from sheep IgG |
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What is Murononab-CD3 (OKT3) used to treat?
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this is an anti rejection drug
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What is ATGAM used to treat? what is it?
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this is an animinal immunoglobulin.
used for renal transplant pts |
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What does RhoGAM do? what is it?
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this is an antibody.
used to clear fetal RBC's from mom's blood, and elicits phagocytic clearance of these cells |
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What is the brand name for Cetuximab? what does it do? what type of drug is it?
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Erbitux
this is a monocolonal antibody agaisnt the EGF-receptor. prevents growth factor binding |
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What does Rituximab do? what is its brand name?
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this works against CD20 on B-cells.
treats non hodgkin lymphoma Rituxan |
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What does Daclizumab do? what is the brand name?
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Zenepax
this is used against IL-2 receptors, keeping T-cells from being activated (opposite of Proleukin) |
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What does Omalizumab do? what is the brand name?
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Xolair
binds to IgE- relieves asthma and allergic rhinitis |
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What does Ipilimumab do? what is the brand name?
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Yervoy
antibody against CTLA-4 cancer treatment |
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What does Mylotarg do? what does it treat?
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this targets CD-33, and carries the toxin Calicheamicin.
(active at pH 4....where?) |
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What is used to treat digoxin poisoning? what kind of drug is this?
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Digibind-
this is a polyclonal antigioxin FAB fragment, made from sheep IgG |
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What is Murononab-CD3 (OKT3) used to treat?
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this is an anti rejection drug
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What is ATGAM used to treat? what is it?
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this is an animinal immunoglobulin.
used for renal transplant pts |
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What does RhoGAM do? what is it?
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this is an antibody.
used to clear fetal RBC's from mom's blood, and elicits phagocytic clearance of these cells |
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What is the brand name for Cetuximab? what does it do? what type of drug is it?
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Erbitux
this is a monocolonal antibody agaisnt the EGF-receptor. prevents growth factor binding |
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What does Rituximab do? what is its brand name?
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this works against CD20 on B-cells.
treats non hodgkin lymphoma Rituxan |
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What does Daclizumab do? what is the brand name?
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Zenepax
this is used against IL-2 receptors, keeping T-cells from being activated (opposite of Proleukin) |
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What does Omalizumab do? what is the brand name?
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Xolair
binds to IgE- relieves asthma and allergic rhinitis |
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What does Ipilimumab do? what is the brand name?
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Yervoy
antibody against CTLA-4- found on helper T cells, gives an inhibitory signal usually cancer treatment |
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What does Mylotarg do? what does it treat?
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this targets CD-33, and carries the toxin Calicheamicin.
(active at pH 4....where?) it treats acute myelogenous leukemia |
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What does Zevalin carry? what does it treat?
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this carries Yttrium-90
treats non-hodgkin lymphoma |
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What does Bexxar carry? what does it treat?
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this carries Iodine-131
treats non-hodgkin lymphoma |
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how much tissues do zevalin and bexxar damage? why?
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these damage a few cells near the target cell.
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Which drug would you use first? Rituxan or Bexxar?
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Rituxan comes first, it is less aggressive (CD-20 antibody)...Bexxar is nuclear medicine carrying Iodine-131
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