Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
IL 1
|
Produced by monocytes and macrophages to activate T cells, induce fever and acute phase response proteins via hepatocytes
|
|
|
IL 2
|
Secreted by Th1 (with INFg) to activate T cell proliferation and Treg maintenance
|
|
|
IL 3
|
Secreted by thymic epithelial cells and T cells to work with IL5 and GM-CSF in hematopoiesis and cell proliferation via HSCs, NK cells, LAK cells
|
|
|
IL 4
|
Secreted by Th2 (with IL5 and IL13) and by mast cells to induce Ig class switching and B cell proliferation
|
|
|
IL 5
|
Secreted by Th2 (with IL4 and IL13) and by mast cells to induce eosinophil hematopoiesis and increase IgG1 production
|
|
|
IL 6
|
Secreted by T cells, macrophages and endothelial cells to induce B cell growth, differentiation and Ig secretion. It also indirectly induces acute phase responses proteins. IL6 promotes inflammation and Th17 responses.
|
|
|
IL 7
|
Secreted by bone marrow and thymic stroma to causes preB cell and preT cell proliferation and naive T cell maintenance
|
|
|
IFN g
|
Secreted by Th1 and cytotoxic T cells (with IL2) to activate cytotoxic T cells, macrophages and NK cells by increasing MHC expression. Also has direct antimicrobial activity
|
|
|
CTLA 4
|
Secreted by Treg cells to down regulate activation of other T cells
|
|
|
IL 10
|
Secreted by Th2, Treg cells, B cells, and macrophages to inhibit NK cells and macrophage function by decreasing cytokine production- and inhibit Th1 cytokines
|
|
|
CD 40
|
Located on B cells. Stimulated by CD40 ligand on Th2 cells to activate Ig class switching.
|
|
|
IL 12
|
Secreted by dendritic cells to initiate an adaptive immune response and causes Th1 cell polarization
|
|
|
Chemokines
|
Short-acting signals produced by immune system cells involved in cell migration and spatial organization of the immune system.
|
|
|
Cytokines
|
Short-acting autocrine and paracrine hormones produced by immune system cells to regulate immune function
|
|
|
IL 13
|
Secreted by Th2 with IL4 and IL5 to help in the antibody-mediated response
|
|
|
IL 17
|
Secreted by Th17 with IL23 to play a role in mucosal, skin, and parasite immunity. Also key player in autoimmunity and tissue destruction
|
|
|
IFN-I
|
Produced by dendritic cells to cause general antiviral and anti proliferative action in somatic cells and initiate an adaptive immune response by serving as the third signal in T cell activation
|
|
|
GM-CSF
|
Secreted by monocytes and T cells to stimulate myelomonocytic precursors and dendritic cells in bone marrow to differentiate into granulocytes and monocytes
|
|
|
G-CSF
|
Secreted by monocytes and fibroblasts to generally stimulate bone marrow to produce more neutrophils via granulocytes and precursor cells
|
|
|
TGFb
|
Produced by CD4 T cells and monocytes to inhibit macrophage activation via T cells and generally inhibit cell growth. Also TGFb stimulates Treg and Th17 differentiation.
|
|
|
TNFa
|
Secreted by macrophages, NK cells, and T cells to cause local inflammation, endothelial cell activation and part of the acute phase response
|
|
|
IL 23
|
Secreted by Th17 with IL17 to play a role in mucosal, skin, and parasite immunity. Also key player in autoimmunity and tissue destruction. Can activate granulocytes which can be hepatotoxic.
|
