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24 Cards in this Set
- Front
- Back
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when would you use cytokine therapy?
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suppress autoimmune disease or suppress graft rejection
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3 cytokines used in therapy?
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type 1 interferons, gamma-interferon, and IL-2
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what do type 1 inf do?
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interfere w/ viral replication and inhibit lymph proliferation
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what diseases would you use type 1 inf for?
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hcv, ms
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gamma-interf. used when?
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chronic granulomatous disease
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il-2 used when?
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hiv or cancer (will create more anti-tumor cells)
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what do cyclosporine and tacromilus do?
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inhibit cytokines; immunosuppress
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when would you give stem cell therapy?
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severe aplastic anemia; leukemia; immunodeficiency disease; inborn errors of metabolism
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what are immunodeficiency diseases?
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scids, chronic granulomatous disease, wiskott-aldrich syndrome
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how do steroids work?
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decrease ability of immune cells to get to inflammatory site
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how do steroids get into cell?
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lipid solube; binds to cytoplasmic receptor, then to nucleus
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steroids can affect which cellular mechanisms?
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transcription
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steroids are doc for which disease?
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autoimmune
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ivig used to treat what?
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immunodeficiency, autoimmune, rabies, hepatitis, rhogam
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spelectomy indicated when?
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bleeding disorder
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what disease has antibodies to rbc?
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immune hemolytic anemia
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2 permanent contraind. for vaccine?
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anaphylaxis; pertussis resulting in encephalpathy
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generally speaking, what two populations should avoid live vaccines?
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pregnant and immunosupp.
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examples of live vaccines? inactivated?
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mmr, varicella, rotavirus; dtap, hcv, hbv
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what common drug is included in immunosupp.
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nsaids
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what are 4 cytotoxic drugs? what cells do they act on?
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cyclophosphamides, azathioprine, methotrexate, and chlorambucil; actively dividing cells (lymphs)
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what are monoclonal antibodies?
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mono-specific reagent antibodies against specific epitopes
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plasmapheresis used in what disease?
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myasthenia gravis
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what is an adjuvant? e.g.?
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something that non-specifically enhances immune response to antigen; alum
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