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27 Cards in this Set
- Front
- Back
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What stimulates transcription of genes in T cells?
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Transcription factors.
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What occurs after antigen recognition in T cells?
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Activation
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What occurs as a result of activation by T cells?
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Transcription factors are released
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The genes that are transcribed as a result of the transcription factors, what do they do?
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Mediate the responses of T cells
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What will phosphorylation of molecules lead to?
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Production of a few proteins
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We have a t cell that is an effector cell thath has abandoned the lymphnodes. How does it recognize the place of infection to move?
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Lose junctions and increased adhesion molecules.
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What happens to T cells that recognize antigens in the extravascular tissues?
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They are retained by integrin-mediated adhesion to the extracellular matrix to kill the infection.
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What happens to t cells that don’t recognize the antigens in the extravascular tissues?
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They return to circulation
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Steps of activation in CD8T cells?
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They will activate. Proliferate. Either become memory cells to stay there in increased numbers incase of returned infection. Some will become effector cells and kill infected target cells
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What MHC does cd4 interact with?
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2
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What MHC does CD8 interact with?
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1
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What is the best scenario for a effector?
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There will be a helper cell that recognizes the T cell and they will stimulate eachother.
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What does an effector cell do to a virus infected cell?
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Murder
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Can a CD8 be activated soley by an APC?
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Yes
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What is the purpose of adhesion molecules in terms of CD8?
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They allow for longer cell-cell interaction. The cell will use it to bind, kill, detach, and bind to another cell.
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What happens if the T cell binds with the target?
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Clustering of receptors, re-organization of cortical actin cytoskeleton, relocation of golgi, exocytosis at site of contact (release the granules), detachment.
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What does CTL induce in target cells?
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Apoptosis
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How will a T cell recognize infected cells
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the cell is carrying the specific peptide of a specific virus that the cell is looking for.
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Difference between necrosis and apoptosis
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necrosis the cell bursts, leading to an inflammatory response. Apoptosis will decintegrate the cell into particles to be ingested by macrophages.
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Will CD8 kill via apoptosis or necrosis?
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Apoptosis
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What are the mechanisms T cells use to kill target cells?
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Secretion of perforin and granules. Interaction with membrane-associated factors
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How do granzymes induce apoptosis?
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They reach the mitochondria.
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Define serglycin
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proteoclycan which acts as a scaffold forming complex with perforin and granzymes
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Apoptosis via FASL is specific or not?
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Not.
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What is FAS?
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Numor necrosis factor. It binds to L and has a death domain that will induce apoptosis.
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What do perforins do?
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Pores in the cytoplasm to allow granzymes to get in
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What does CTL do?
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Harbor proteins in granules that are released upon close contact with target.
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