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25 Cards in this Set
- Front
- Back
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MAC is composed of which complement proteins?
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C6, C7, C8, C9
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Which antibody class is small enough to cross the placenta?
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IgG
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What is the initiating factor in the classical complement pathway?
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Immune complexes
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What is the initiating factor in the alternative complement pathway?
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Direct antigenic recognition
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Which antibody class is present in breast milk, tears, and other body fluids?
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IgA
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Which antibody class mediates allergic reactions and parasitic infections?
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IgE
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Which antibody class is the most effective at activating complement?
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IgM
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C1, C2, and C4 are seen in which complement pathway?
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Classical
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The site that an antibody binds to an antigen is known as the:
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Epitope or antigenic determinant
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An excess of antibody compared to antigen is known as:
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Prozone
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An excess of antigen compared to antibody results in
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Postzone
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An equivalent number of antigens and antibodies results in:
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Zone of equivalence
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Define serology
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Study of antibodies and their corresponding antigens
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Which antibody classes do naive B cells display?
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IgM and IgD
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What is another term for secondary response?
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Anamnestic
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The pairing of the antigen with the antibody results in the formation of the:
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Immune complex
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What are the factors that determine how antigenic a substance can be?
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Foreignness, degradability, molecular weight, stability, complexity
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What is the sequence of events in an immune response?
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Lag--> Log--> Plateau--> Decline
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What changes can be noted in a primary response and a secondary response?
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Longer plateau, shorter lag, change in antibody class, more gradual decline, greater antibody titers
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Define opsonization.
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The coating of an antigen to mark it for phagocytosis
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What is the function of C3a?
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Promotes inflammation by binding to mast cells and basophils and stimulating them to release their granule contents
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What is the name for a macrophage that is located in the liver?
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Kupffer cell
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What is a pathogen-associated molecular pattern (PAMP)?
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Sequence that is present on a microbial surface but not on mammalian cells that can be detected by the innate immune system
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What type of pattern recognition receptor (PRR) binds to carbon molecules and is dependent on calcium?
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C Type Lectin
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Defensins that act against antigens in the intestines are called?
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Crypticidins
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