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21 Cards in this Set
- Front
- Back
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Defense against ingested microbes
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Th1 cells
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Defense against infected cells with microbes in cytoplasm
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CTLs
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Anatomical site of activation of naive T cells
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Lymphoid organs
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Anatomical site of antigen elimination by effector T cells
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Peripheral tissues
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Homing molecules on activated T cells
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E- and P-selectin ligand, LFA-1 or VLA-4, CXCR3
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Homing molecules on naive T cells
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L-selectin, LFA-1, CCR7
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Immune-mediated tissue damage
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Hypersensitivity
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Effector cell of delayed-type hypersensitivity (DTH)
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Macrophage
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Major cytokine that activates macrophages to kill ingested microbes
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IFNg
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Skin test that detects DTH response to Mycobacteria
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PPD
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Time frame to elicit a DTH reaction
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24-48 hours
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Mechanisms of damage in DTH
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Macrophages, CTLs, granulomatous inflammation
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Chronic CMI response to TB
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granulomas
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Defense against helminth infections
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IgE and IL-5-activated eosinophils
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Enzymes that cleave and activate caspases
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Granzymes
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Protein necessary for delivery of granzymes into target cells
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Perforin
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Mechanism of CTL-mediated killing of target cell
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Apoptosis
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Cytokines that inhibit microbicidal activity of macrophages
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IL-4, IL-10, IL-13
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Activating signals for CTLs
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Antigen recognition & firm adhesion
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Viral-induced mechanism of immune evasion
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Inhibit antigen presentation
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Mycobacteria-induced mechanism of immune evasion
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Inhibit phagolysosome fusion
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