• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/32

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

32 Cards in this Set

  • Front
  • Back
Processed peptides bound to MHC molecules
T cell antigens
Recognition by T cells of peptides bound to one’s own MHC molecules
MHC restriction
Cells that capture and present peptides to T cells
Antigen-presenting cells (APC)
Dendritic cells, macrophages, B cells
Professional APC’s
Another name for immature dendritic cell in the skin
Langerhans cell
Transports antigen from epithelia to draining lymph node
Dendritic cells
Destination of antigens captured in epithelia and sub-epithelial tissues
Lymph nodes, MALT, GALT, BALT
Destination of blood-borne antigens
Spleen
Microbial-induced activators of dendritic cells
TNF, IL-1, TLR signaling
Destination of dendritic cells in lymph nodes
T cell zones
Chemical signal that attracts activated dendritic cells to draining lymph node
Chemokines that bind to CCR7 on dendritic cell
Afferent lymphatic vessel—lymph node---efferent lymphatic vessel
Flow of lymph through a draining lymph node
Human Major Histocompatibility Complex (MHC) proteins
Human Leukocyte Antigens (HLA)
Genes that encode the Class I MHC molecules
HLA-A, B, C
Cells that express Class I MHC molecules
All nucleated cells
Genes that encode the Class II MHC molecules
HLA-DP, DQ, and DR
Cells that express Class II MHC molecules
Professional APC’s
Set of MHC alleles present on each chromosome
MHC haplotype
MHC molecules that are recognized by CD8+ T cells
Class I
MHC molecules that are recognized by CD4+ T cells
Class II
Domains of peptide-binding groove of MHC Class I molecules
α1:α 2
CD8 binding site of MHC Class I molecule
α 3
Domains of peptide-binding groove of MHC Class II molecules
α1:β1
CD4 binding site of MHC Class II molecule
β2
Source of antigens for MHC Class I molecules
Endogenous cytosolic proteins
Source of antigens for MHC Class II molecules
Endosomes/Lysosomes
Site of peptide loading for MHC Class I molecule
Endoplasmic reticulum
Site of peptide loading for MHC Class II molecule
Vesicle
Enzymes that generate peptides for MHC Class I molecules
Proteasome
Enzymes that generate peptides for MHC Class II molecules
Proteases in vesicles
T cell population that responds to peptide: MHC Class II molecules
CD4+ T cells
T cell population that responds to peptide: MHC Class I molecules
CD8+ T cells