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23 Cards in this Set
- Front
- Back
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Defective immune system due to congenital defect
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Primary or congenital immunodeficiency disease
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Defective immune system due to infection, malnutrition, medical treatment
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Secondary or acquired immunodeficiency disease
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Deficiencies in this immune compartment lead to pyogenic bacterial infections
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B cell deficiencies
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Deficiencies in this immune compartment lead to viral, fungal and other intracellular bacterial infections
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T cell deficiencies
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Deficiencies in this immune compartment lead to variable types of infection depending on specific defect
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Innate immune deficiencies
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Lack of B and T cell-mediated immune responses
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SCID
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Defects in these genes impairs lymphocyte development
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ADA, PNP, RAG, ZAP-70 or gc chain genes
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Decreased Ig levels caused by defect in Bruton’s tyrosine kinase
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XLA
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Immunologic consequence of abnormal development of 3rd and 4th branchial pouches
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Thymic hypoplasia
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Disease marked by lack of CMI due to thymic hypoplasia
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DiGeorge Syndrome
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Disease marked by elevated levels of IgM, decreased levels of other antibody classes and decreased CMI
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X-linked hyper-IgM syndrome
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Consequence of defective CD40-CD40L signaling between T & B cells
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No isotype switching
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Selective deficiency of IgG, IgA and or IgM due to defects in heavy chains
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Common variable immunodeficiency
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Disease due to deficiency of MHC Class I or II molecules
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Bare lymphocyte syndrome
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Defective T cell responses due to abnormal antigen processing
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Bare lymphocyte syndrome
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Disease with defective microbicidal killing by phagocytes due to mutation in phagocyte oxidase
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Chronic granulomatous disease
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Laboratory test that detects defective phagocyte killing
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Nitroblue tetrazolium test
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Disease with chronic bacterial and fungal infections
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Chronic granulomatous disease
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Disease where defective or absent CD18 results in lack of leukocytes at site of infection
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Leukocyte adhesion deficiency
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Disease with recurrent bacterial infections due to defective lysosomal function
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Chediak-Higashi
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Disease where defective cytoskeleton components leads to abnormally small platelets and leukocytes
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Wiskott-Aldrich syndrome
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Disease marked by deficient activation of classical complement pathway
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Lupus-like diseases
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Immunologic consequence of C2 and/or C4 deficiency
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Failure to clear immune complexes
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