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30 Cards in this Set

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adoptive immunity
immunity conferred on a naive or irradiated recipient by transfer of lymphoid cells from an actively immunized donor
antibody
protein that binds specifically to a particular substance or antigen, they are produced by plasma cellsin responce to infection or immuniation, bind to and neutralize pathogens or prepare them for uptake and destruction by phagocytes
antigen
any molecule that can bind specifically to an antibody, generate antibodies
immunogens
can induce antibody production
antigen presenting cells
highly specialized cells that can process antigens and display their peptide fragments on the cell surface together with molecules required for T cell activation,
dendritic cells, macrophages, Bcells
immune
free from burden
immune system
organization of tissues, cells, molecules wcich specialize in defending the host against infections
three major functions of the immune system
defend the host against pathogens
surveillance the body
maintain homeostasis
two divisions of the immune system
innate(natural)immunity
acquired(specific adaptive)immunity
edward jenner
vaccination
robert koch
postulates
louis pasture
attenuated vaccine
elie metchnikoff
phagocytosis
paul ehrlich
side chain theory of Ab production
Jerne and Burnet
clonal selection theory
kohler and milstein
monoclonal Ab
hematopoiesis
formation and development of the blood cells in the bone marrow
ERYTHROID AND MEGAKARYOCYTE PRECURSORS
eruthrocytes, platlets
MYELOID PRECURSORS
Granulocytes-> neotrophil,basophil, eosinophil
lymphoid precursor
lymphocytes->B and T cells and NK cells
neotrophils
60-70% of circulating WBC
main phagocyts in the bogy
can enter the tissue
basophils
0.5-1% of circulating WBC
function in inflammation and allergies
similar to Mast cell of the tissue
eosinophils
2-4% of circulating WBC
function in allergies and helminth infections
may be phagocytic
monocytes
3-8% of circulating WBC
once enter the tissue become macrophages
phagoytes
precess Ag
secret cytokines
involved in both Innate and Adaptive immunity
cytokine
small biologiclly active molecule secreted by cells to effect the behavior of another cell
naive lymphocyte
not yet seen foreign Ag
mature lymphocyte
expresses a fuctional specific Ag receptor
APC
highly specialized cells that can process antigens and display their peptide fragments on the cell surface together with molecules required for Tcell activation
Dendritic cells, macrophages, B cells
macropinocytosis
take up extracellular material, receptor independent mechanism
clonel selection theory
1.each lymphocyte has a single type of receptor with unique specificity
2.interaction between Ag and lymphocytes leads to activation-prolifiration and differentiation
3.progeny have all the same receptor specificity as the parent cell
4.self reacted lymphocytes are deleted