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30 Cards in this Set
- Front
- Back
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adoptive immunity
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immunity conferred on a naive or irradiated recipient by transfer of lymphoid cells from an actively immunized donor
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antibody
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protein that binds specifically to a particular substance or antigen, they are produced by plasma cellsin responce to infection or immuniation, bind to and neutralize pathogens or prepare them for uptake and destruction by phagocytes
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antigen
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any molecule that can bind specifically to an antibody, generate antibodies
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immunogens
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can induce antibody production
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antigen presenting cells
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highly specialized cells that can process antigens and display their peptide fragments on the cell surface together with molecules required for T cell activation,
dendritic cells, macrophages, Bcells |
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immune
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free from burden
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immune system
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organization of tissues, cells, molecules wcich specialize in defending the host against infections
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three major functions of the immune system
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defend the host against pathogens
surveillance the body maintain homeostasis |
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two divisions of the immune system
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innate(natural)immunity
acquired(specific adaptive)immunity |
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edward jenner
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vaccination
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robert koch
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postulates
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louis pasture
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attenuated vaccine
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elie metchnikoff
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phagocytosis
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paul ehrlich
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side chain theory of Ab production
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Jerne and Burnet
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clonal selection theory
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kohler and milstein
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monoclonal Ab
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hematopoiesis
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formation and development of the blood cells in the bone marrow
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ERYTHROID AND MEGAKARYOCYTE PRECURSORS
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eruthrocytes, platlets
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MYELOID PRECURSORS
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Granulocytes-> neotrophil,basophil, eosinophil
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lymphoid precursor
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lymphocytes->B and T cells and NK cells
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neotrophils
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60-70% of circulating WBC
main phagocyts in the bogy can enter the tissue |
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basophils
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0.5-1% of circulating WBC
function in inflammation and allergies similar to Mast cell of the tissue |
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eosinophils
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2-4% of circulating WBC
function in allergies and helminth infections may be phagocytic |
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monocytes
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3-8% of circulating WBC
once enter the tissue become macrophages phagoytes precess Ag secret cytokines involved in both Innate and Adaptive immunity |
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cytokine
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small biologiclly active molecule secreted by cells to effect the behavior of another cell
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naive lymphocyte
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not yet seen foreign Ag
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mature lymphocyte
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expresses a fuctional specific Ag receptor
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APC
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highly specialized cells that can process antigens and display their peptide fragments on the cell surface together with molecules required for Tcell activation
Dendritic cells, macrophages, B cells |
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macropinocytosis
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take up extracellular material, receptor independent mechanism
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clonel selection theory
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1.each lymphocyte has a single type of receptor with unique specificity
2.interaction between Ag and lymphocytes leads to activation-prolifiration and differentiation 3.progeny have all the same receptor specificity as the parent cell 4.self reacted lymphocytes are deleted |
