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29 Cards in this Set
- Front
- Back
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Tumor Supressor Genes
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genes that encode products that inhibit excessive cell proliferation
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Tumor specific transplantation antigens
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antigens that are unique to tumor cells
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Tumor infiltrating lymphocytes
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Lymphocyte populations with anti-tumor activity obtained by taking small biopsy samples of tumors
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Tumor associated transplantation antigens
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Antigens that are expressed on particular tumors or types of tumors that are not unique to tumor cells
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Tumor Necrosis Factors
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Two related cytokines produced by macrophages (TNF-alpha) and come T cells (TNF-beta); both factors are cytotoxic to tumor cells but not to normal cells; they also play a role in inflammatory responses
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Tumor Antigens
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Cell surface proteins present on the surface of tumor cells that can induce a cell mediated immune response; some are found only on tumor cells; others are found on normal cells
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Transformation
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Change that a normal cwell undergoes as it becomes malifnant, also, permanent, heritable alteration in a cell resulting from the uptake and incorporation of foreign DNA into the genome
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Sarcoma
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Tumor of supporting or connective tissue
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Rous Sarcoma Virus
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A retrovirus that induces tumors in avian species
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RetroVirus
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A type of RNA virus that uses a reverse transcriptase to produce a DNA copy of its RNA genome; HIV which causes AIDs, and HTLV, which causes adult t-cell leukemia, both are retroviruses
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Proto-oncogene
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A cancer associated gene that encodes a factor that regulates cell proliferation, survival, or death; its is required for normal cell function but if mutated or produced inappropriate amounts, it becomes an oncogen, which can cause transformation of the cell
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Oncogenic
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Causing cancer
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Oncogene
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A gene that encodes a protein capable of inducing cellular transformation; oncogenes derived from viruses are written v-onc; their counterparts (proto-oncogenes) in normal cells are written c-onc
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Oncofetal tumor antigen
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An antigen that is present during fetal development, but generaly is not expressed in tissues except by tumor cells; alpha feto protein (AFP_ and carcinoembryonic antigen (CEA) are two examples that have ben associated with various cancers
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Neoplasm
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Any new and abnormal growth; a benign or malignant tumor
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Metastasis
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The colinization by tumor cells of sites distant from the primary site
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Malignant
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Resistant to treatment or fatal; refers to uncontrolable recurring neoplasms
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Lymphoma
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A cancer of lymphoid cells that tends to proliferate as a solid tumor
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Lymphokine activated killer cell
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Anti-tumor cells generated by terating peripheral blood leukocytes of tumor patients with high concentrations of IL-2; they are derived from NK cell population
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Leukemia
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Cancer originating in a class of hematopoietic cells that tends to proliferate as single cells within the lymph or blood
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Karposi's Sarcoma
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A mep[;astoc ;esopm cjaracterozed by multiple bluish nodules in the skin and hemorrhages; its common in aids patients
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Chronic myelogenous leukemia
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A type of leukemia in which cells of the myeloid lineage are continually produced
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Chronic lymphocytic Leukemia
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A type of leukemia in which cancerous lymphocytes are continually produced
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Carcinoma
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Tumor arising form endodermal or ectodermal tissues (skin or epithelium); most cancers are carcinomas
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Carcinoembryonic antigen
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An oncofetal antigen (found not only on cancerous cells but also in normal cells) that can be a tumor associated antigen
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Benign
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Pertaining to nonmalifnant form of a neoplasm or a mild form of an illness
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Alpha-feto protein
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see oncofetal tumor antigen
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Acute myelogenous lekemia
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a form of cancer in which there is uncontrolled proliferation of a cell of the myeloid lineage; the proliferating cells usually are present in the blood
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Acute lymphocytic leukemia
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A form of cancer in which there is uncontroled proliferation of a cell of the lymphoid lineage; the proliferating cells usualy are present in the blood
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