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7 Cards in this Set
- Front
- Back
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what will pharmacogenetics allow?
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2 million people get really sick every year from normal prescriptions. also, a lot of prescriptions aren't approved because a subset of people get sick from them.
we'll have more drugs and better dosing. |
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what can genetics have to do with drugs? why is succnylcholine particularly interesting here?
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change absorption rate, metabolism, elimination, and variations in the receptors that the drug is targeting.
succnylcholine is a muscle relaxant that's broken down by pseudocholinesterase, a plasma enzyme. note that there's a great amount of variability in the activity of this enzyme between people. Can lead to apnea. |
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what's the issue with glucose 6 phosphate dehydrogenase deficiency?
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if you give pimaquin or other anti-malarials, get extreme hemolytic anemia. especially common in black males.
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what's the acetylator phenotype and what drugs/diseases can be associated with it?
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slow acetylators: they have a varient in acetyltransferase.
40-60% of caucasiand, 80% of arabs, and 20% of japanese. Procanamide is one drug that ends up in too high a concentration, and we know that they can experience lupus-like symptoms with neuritis and bladder cancer. also, isonaiozide - this is anti TB and people who are slow acetylators can end up with peripheral neuropathy. note that this probably also applies to sulfa drugs and dapsone |
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how is 5-flouro-uracil changed by genetics?
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dihydro pyramadine dehydrogenase deficiency (DPD) is a condition seen in between 1 and 3% of cancer patients.
makes the half life from 13 minutes to 160 minutes, so get a lot of toxcisity from it. screws up BM and GI. |
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what is gleevec, what disease does it treat, and what's its mechanism of action?
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gleevec is used to treat CML.
Remember that CML is often caused by a "philadelphia" chromosome - a fusion of 9:22 translocation. Get the Bcr-Abl fusion protein made. Gleevec blocks the action of the Bcr-Abl |
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what do we test for in warfarin dosing?
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variants in CYP 29c and VKORc1
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