Immunology - Antibodies - (Som Fall 2011)

Front 1

Antibodies: Basic Structure?

Back 1

Monomeric unit:
- 2 identical light chains
covalently linked to
2 identical heavy chains.

Each light and heavy chain has
a Variable region (N-terminal) & a Constant Region (C-Terminal)

Front 2

How many Monomeric units can exsit?

Which are composed of how many?

Back 2

Dimeric, trimeric, pentameric Forms of immunoglobulins.

2, 3, 5 monomeric units respectively.

Front 3

Antibodies are also know as?

Which are?

Back 3

Immunoglobulins.

Heterogeneous bifunctional Gylcoproteins secreted by differentiated B cells, termed plasma cells.

Front 4

Light chains Constant regions have how many classes?
What are they?

Which is the predominant one?

Back 4

2 Classes.
Kappa & Lamda

Kappa is predominant.
Lambda is there too.
But mostly Kappa in the poplulation.

Front 5

Heavy chains has how many Classes?
How are they distiguished?

Back 5

-5 major Classes:
-distinguished by differing Constant
Alpha (α), Delta (δ), Epsilon (ε), Gamma (γ), Mu (μ).

which gives rise to antibody isotypes: IgA, IgD, IgE, IgG and IgM.

Front 6

Heavy Chain Constant Regions give rise to Antibody Isotypes:
What are they?

Back 6

IgA, IgD, IgE, IgG and IgM.