Immunology

Front 1

CD2 (AKA?)

expressed on?

Back 1

(LFA-2)

T cells, thymocytes, NK Cells

Front 2

CD2

function?

Back 2

adhesion molecule

Front 3

CD3
expressed on?

Back 3

T cells and thymocytes

Front 4

CD3
function?

Back 4

Transducing TCR signal

Front 5

CD4

expressd on (primarily)?

Back 5

TH cells

Front 6

CD4

expressed on (secondary)

Back 6

thymocytes, monocytes and Macrophages

Front 7

CD4
function

Back 7

Coreceptor for TCR-MHC II interaction

Front 8

CD4
associated pathology

Back 8

-receptor for HIV

-absent in Bare Lymphocyte syndrome

Front 9

CD8

expressed on?

Back 9

CTLs, thymocytes

Front 10

CD8

function

Back 10

co-receptor for TCR-MHC I

Front 11

CD14
AKA

Back 11

LPS receptor

Front 12

CD14

expressed on

Back 12

Mono/mac's, granulocytes

Front 13

CD14

function

Back 13

binds LPS (shocking)

Front 14

CD16
AKA

Back 14

FcR

Front 15

CD16

expressed on

Back 15

NK cells
Mac's
PMN's

Front 16

CD16

function

Back 16

opsonization

ADCC

Front 17

CD18

comprises what molecule?

Back 17

the B chain of LFA-1 family

Front 18

CD18

expressed on?

Back 18

Leukocytes

Front 19

CD18

function

Back 19

Cell adhesion

Front 20

CD18

associated pathology

Back 20

absent in leukocyte adhesion deficiency

Front 21

CD19

expressed on

Back 21

B cells

Front 22

CD19

function

Back 22

coreceptor (w/ CD21) for B-cell activation

Front 23

CD20

expressed on

Back 23

B cells

Front 24

CD21

expressed on

Back 24

mature B cells

Front 25

CD21
function

Back 25

- Receptor for complement frag. C3d

- forms coreceptor complex with CD19

Front 26

CD21

associated pathology

Back 26

EBV receptor

Front 27

CD28

expressed on?

Back 27

T cells

Front 28

CD28

function

Back 28

binds to B-cell B7 (costim. molecule)

Front 29

CD34

expressed on?

Back 29

-hematopoietic precursor cells

-HEV endothelium

Front 30

CD34

general function (molecular function)

Back 30

Cell-cell adhesion
(binds L-selectin)

Front 31

CD40

expressed on (most importantly)?

Back 31

B cells

Front 32

CD40

expressed on (less important)

Back 32

Mac's
DC's
endothelium

Front 33

CD40

molecular function

Back 33

binds to T Cell CD40L

Front 34

CD40

general function

Back 34

key in T cell dependent B cell (and other APC) activation

Front 35

CD45

expressed on

Back 35

hematopoeitic cells

Front 36

CD45

function

Back 36

TCR and BCR signalling

Front 37

CD56

marker for

Back 37

NK cells

Front 38

IL1

secreted by

Back 38

Mono/mac's
B Cells
DC's

Front 39

IL1

T helper effect

Back 39

costimulation

Front 40

IL1

B Cell effect

Back 40

promotes maturation and clonal expansion

Front 41

IL1

NK cell effect

Back 41

enhanced activity

Front 42

IL1

endothelial effect

Back 42

upregulate ICAM expression

Front 43

IL1

Mac and PMN effect

Back 43

chemoattractant

Front 44

IL1

hepatocyte effect

Back 44

induces synthesis of acute phase reactants

Front 45

IL1

hypothalamic effect

Back 45

increases body temp. set point

Front 46

IL2

produced by

Back 46

TH cells

Front 47

IL2

function and target

Back 47

induces proliferation of TH AND CTL's

Front 48

IL3

secreted by

Back 48

TH and NK cells

Front 49

IL3

AKA

Back 49

GM-CSF

Front 50

IL3
function

Back 50

supports growth and differentiation of the myeloid cell lines

Front 51

CD14 is best used as a marker in flow analysis for?

Back 51

Macrophages

Front 52

Early Leukocyte-endothelial adhesion (IE rolling) is mediated by

Back 52

selectin-addressin interaction

Front 53

Late, strong Leukocyte-endothelial adhesion is mediated by

Back 53

Integrin-ICAM interaction

Front 54

CD2

ligand?

Back 54

LFA-3

Front 55

IL4

secreted by

Back 55

TH2

Front 56

IL4

effect on antigen-primed B cells (less important)

Back 56

costim. activation

Front 57

IL4

effect on activated B Cells (more important)

Back 57

induces isotype switching to IGE and IgG1

Front 58

IL5

secreted by

Back 58

TH2

Front 59

IL5

function

Back 59

-stims proliferation and differentiation of B cells

-induces class switch to IgA

Front 60

IL10

secreted by and function

Back 60

secreted by TH2

it suppresses TH1 cytokine production

Front 61

IL6
(secreted by)

function in terms of B cells

Back 61

(TH2)

-promotes terminal differentiation of B-cells into plasma cells and Ig production

Front 62

IL7

secreted by

Back 62

bone marrow

thymic stromal cells

Front 63

IL7

function

Back 63

induces differentiation of lymphoid progenitor cells

Front 64

IL8

secreted by

Back 64

Macrophages

endothelium

Front 65

IL6

function in terms of hepatocytes

Back 65

induces synthesis of acute-phase proteins

Front 66

IL6

myeloid stem cell function

Back 66

promotes differentiation.

Front 67

Il8

function

Back 67

serves as a chemoattractant for PMNs and induces adhesion/extravasation

Front 68

IL12

function

Back 68

acts synergistically with Il-2 to induce diff. of CTLs

Front 69

IL12

stimulates the proliferation of

Back 69

NKs

activated TH1

Front 70

Ifn A

target

Back 70

uninfected cells

Front 71

Ifn A

secreted by

Back 71

leukocytes

Front 72

Ifn A

function

Back 72

inhibits viral replication

Front 73

Ifn B

secreted by

Back 73

fibroblasts

Front 74

Ifn B

target cells

Back 74

uninfected cells

Front 75

Ifn B

function

Back 75

inhibits viral replication

Front 76

Ifn Y

secreted by

Back 76

Th1

Front 77

ifn Y

functions

Back 77

- enhance mac activity

-upregulation of MHC I and II

- blocks IL4 effect on B cells

Front 78

What is the key cytokine mediator of DTH?

Back 78

ifn Y

Front 79

TGF-B

target cells

Back 79

proliferating B cells

Front 80

TGF-B

function

Back 80

aids in class switching to IgA

Front 81

TNF-A

secreted by

Back 81

macrophages

Front 82

TNF-A

effect on tumor cells

Back 82

cytotoxic

Front 83

name the factor reponsible for cachexia

Back 83

TNF A

Front 84

TNF-A

effect on inflammatory cells

Back 84

induces cytokine secretion

Front 85

TGF-B

key effect in terms of inflammation

Back 85

TGF-B inhibits proliferation and effector function of lymphcytes and Macs

Front 86

TNF B

effects

Back 86

-cytotoxic effects on tumor cells

- enhances phagocytic activity

Front 87

Selectins

key function

Back 87

initiation of rolling interaction between leukocytes and the endothelium

Front 88

Selectins

bind to

Back 88

addressins (CHO)

Front 89

Selectins

which form is expressed on WBC

Back 89

L-selectin

Front 90

Selectins

which form is expressed on endothelium

Back 90

E-Selectin

Front 91

Integrins

function

Back 91

strong adhesion ----> extravasation of WBC

Front 92

Integrins

bind to

Back 92

ICAMs (Ig superfamily)

Front 93

Integrins

LFA-1 binds to

Back 93

ICAMs