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93 Cards in this Set

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CD2 (AKA?)

expressed on?
(LFA-2)

T cells, thymocytes, NK Cells
CD2

function?
adhesion molecule
CD3
expressed on?
T cells and thymocytes
CD3
function?
Transducing TCR signal
CD4

expressd on (primarily)?
TH cells
CD4

expressed on (secondary)
thymocytes, monocytes and Macrophages
CD4
function
Coreceptor for TCR-MHC II interaction
CD4
associated pathology
-receptor for HIV

-absent in Bare Lymphocyte syndrome
CD8

expressed on?
CTLs, thymocytes
CD8

function
co-receptor for TCR-MHC I
CD14
AKA
LPS receptor
CD14

expressed on
Mono/mac's, granulocytes
CD14

function
binds LPS (shocking)
CD16
AKA
FcR
CD16

expressed on
NK cells
Mac's
PMN's
CD16

function
opsonization

ADCC
CD18

comprises what molecule?
the B chain of LFA-1 family
CD18

expressed on?
Leukocytes
CD18

function
Cell adhesion
CD18

associated pathology
absent in leukocyte adhesion deficiency
CD19

expressed on
B cells
CD19

function
coreceptor (w/ CD21) for B-cell activation
CD20

expressed on
B cells
CD21

expressed on
mature B cells
CD21
function
- Receptor for complement frag. C3d

- forms coreceptor complex with CD19
CD21

associated pathology
EBV receptor
CD28

expressed on?
T cells
CD28

function
binds to B-cell B7 (costim. molecule)
CD34

expressed on?
-hematopoietic precursor cells

-HEV endothelium
CD34

general function (molecular function)
Cell-cell adhesion
(binds L-selectin)
CD40

expressed on (most importantly)?
B cells
CD40

expressed on (less important)
Mac's
DC's
endothelium
CD40

molecular function
binds to T Cell CD40L
CD40

general function
key in T cell dependent B cell (and other APC) activation
CD45

expressed on
hematopoeitic cells
CD45

function
TCR and BCR signalling
CD56

marker for
NK cells
IL1

secreted by
Mono/mac's
B Cells
DC's
IL1

T helper effect
costimulation
IL1

B Cell effect
promotes maturation and clonal expansion
IL1

NK cell effect
enhanced activity
IL1

endothelial effect
upregulate ICAM expression
IL1

Mac and PMN effect
chemoattractant
IL1

hepatocyte effect
induces synthesis of acute phase reactants
IL1

hypothalamic effect
increases body temp. set point
IL2

produced by
TH cells
IL2

function and target
induces proliferation of TH AND CTL's
IL3

secreted by
TH and NK cells
IL3

AKA
GM-CSF
IL3
function
supports growth and differentiation of the myeloid cell lines
CD14 is best used as a marker in flow analysis for?
Macrophages
Early Leukocyte-endothelial adhesion (IE rolling) is mediated by
selectin-addressin interaction
Late, strong Leukocyte-endothelial adhesion is mediated by
Integrin-ICAM interaction
CD2

ligand?
LFA-3
IL4

secreted by
TH2
IL4

effect on antigen-primed B cells (less important)
costim. activation
IL4

effect on activated B Cells (more important)
induces isotype switching to IGE and IgG1
IL5

secreted by
TH2
IL5

function
-stims proliferation and differentiation of B cells

-induces class switch to IgA
IL10

secreted by and function
secreted by TH2

it suppresses TH1 cytokine production
IL6
(secreted by)

function in terms of B cells
(TH2)

-promotes terminal differentiation of B-cells into plasma cells and Ig production
IL7

secreted by
bone marrow

thymic stromal cells
IL7

function
induces differentiation of lymphoid progenitor cells
IL8

secreted by
Macrophages

endothelium
IL6

function in terms of hepatocytes
induces synthesis of acute-phase proteins
IL6

myeloid stem cell function
promotes differentiation.
Il8

function
serves as a chemoattractant for PMNs and induces adhesion/extravasation
IL12

function
acts synergistically with Il-2 to induce diff. of CTLs
IL12

stimulates the proliferation of
NKs

activated TH1
Ifn A

target
uninfected cells
Ifn A

secreted by
leukocytes
Ifn A

function
inhibits viral replication
Ifn B

secreted by
fibroblasts
Ifn B

target cells
uninfected cells
Ifn B

function
inhibits viral replication
Ifn Y

secreted by
Th1
ifn Y

functions
- enhance mac activity

-upregulation of MHC I and II

- blocks IL4 effect on B cells
What is the key cytokine mediator of DTH?
ifn Y
TGF-B

target cells
proliferating B cells
TGF-B

function
aids in class switching to IgA
TNF-A

secreted by
macrophages
TNF-A

effect on tumor cells
cytotoxic
name the factor reponsible for cachexia
TNF A
TNF-A

effect on inflammatory cells
induces cytokine secretion
TGF-B

key effect in terms of inflammation
TGF-B inhibits proliferation and effector function of lymphcytes and Macs
TNF B

effects
-cytotoxic effects on tumor cells

- enhances phagocytic activity
Selectins

key function
initiation of rolling interaction between leukocytes and the endothelium
Selectins

bind to
addressins (CHO)
Selectins

which form is expressed on WBC
L-selectin
Selectins

which form is expressed on endothelium
E-Selectin
Integrins

function
strong adhesion ----> extravasation of WBC
Integrins

bind to
ICAMs (Ig superfamily)
Integrins

LFA-1 binds to
ICAMs