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23 Cards in this Set

  • Front
  • Back
What is complement?
System of proteins that interact to play a role in humoral immunity and inflammation
What does complement defend against?
Gram-Negative Bacteria
What activated the Classic pathway?
IgG or IgM

"GM makes Classic cars"
What activates the Alternate pathway?
molecules on the surface of microbes - especially endotoxin
which complement is responsible for:

Viral Neutralization?
C1, C2, C3, C4
which complement is responsible for:

anaphylaxis
C3a, C5a
which complement is responsible for:

Neutrophil Chemotaxis
C5a
which complement is responsible for:

Cytolysis by membrane attack complex (MAC)
C5b-9
Deficiency of ______ leads to hereditary angioedema (overactive complement).
C1 esterase inhibitor
Deficiency of ________ leads to severe, recurrent pyogenic
sinus and respiratory tract
infections.
C3
Deficiency of _________ leads to leads to Neisseria bacteremia.
C6–C8
Deficiency of __________
leads to paroxysmal nocturnal
hemoglobinuria (PNH).
decayaccelerating
factor (DAF)
Deficiency of C1 esterase
inhibitor leads to
hereditary angioedema (overactive complement).
Deficiency of C3 leads to
severe, recurrent pyogenic
sinus and respiratory tract
infections.
Deficiency of C6–C8 leads to
Neisseria bacteremia
Deficiency of decayaccelerating factor (DAF) leads to
paroxysmal nocturnal
hemoglobinuria (PNH).
B27
Psoriasis, Ankylosing spondylitis, Inflammatory bowel disease, Reiter’s syndrome.
B8
Graves’ disease, celiac sprue.
DR2
Multiple sclerosis, hay fever, SLE, Goodpasture’s.
DR3
Diabetes mellitus type 1.
DR4
Rheumatoid arthritis, diabetes mellitus type 1.
DR5
Pernicious anemia → B12 deficiency, Hashimoto’s thyroiditis.
DR7
Steroid-responsive nephrotic syndrome.