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23 Cards in this Set
- Front
- Back
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What is complement?
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System of proteins that interact to play a role in humoral immunity and inflammation
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What does complement defend against?
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Gram-Negative Bacteria
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What activated the Classic pathway?
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IgG or IgM
"GM makes Classic cars" |
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What activates the Alternate pathway?
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molecules on the surface of microbes - especially endotoxin
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which complement is responsible for:
Viral Neutralization? |
C1, C2, C3, C4
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which complement is responsible for:
anaphylaxis |
C3a, C5a
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which complement is responsible for:
Neutrophil Chemotaxis |
C5a
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which complement is responsible for:
Cytolysis by membrane attack complex (MAC) |
C5b-9
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Deficiency of ______ leads to hereditary angioedema (overactive complement).
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C1 esterase inhibitor
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Deficiency of ________ leads to severe, recurrent pyogenic
sinus and respiratory tract infections. |
C3
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Deficiency of _________ leads to leads to Neisseria bacteremia.
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C6–C8
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Deficiency of __________
leads to paroxysmal nocturnal hemoglobinuria (PNH). |
decayaccelerating
factor (DAF) |
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Deficiency of C1 esterase
inhibitor leads to |
hereditary angioedema (overactive complement).
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Deficiency of C3 leads to
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severe, recurrent pyogenic
sinus and respiratory tract infections. |
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Deficiency of C6–C8 leads to
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Neisseria bacteremia
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Deficiency of decayaccelerating factor (DAF) leads to
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paroxysmal nocturnal
hemoglobinuria (PNH). |
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B27
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Psoriasis, Ankylosing spondylitis, Inflammatory bowel disease, Reiter’s syndrome.
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B8
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Graves’ disease, celiac sprue.
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DR2
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Multiple sclerosis, hay fever, SLE, Goodpasture’s.
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DR3
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Diabetes mellitus type 1.
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DR4
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Rheumatoid arthritis, diabetes mellitus type 1.
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DR5
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Pernicious anemia → B12 deficiency, Hashimoto’s thyroiditis.
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DR7
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Steroid-responsive nephrotic syndrome.
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