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36 Cards in this Set

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  • Back
Antibody structure and function
Which part of the light and heavy chain recognizes the antigen?
Variable part
The interchain and intrachain bonds in the antibody are of what type?
Disulfide bonds
What is the term called when the antibody prevents bacterial adherence?
Neutralization
The amino terminal is part of which fragment of the antibody?
Fab fragment
The fab fragment of the antibody is composed of which chain(s)?
Light and heavy chains
Describe the Fc fraction of the B cell receptor.
Constant, Carboxy terminal, Complement-binding (IgG + IgM only), Carbohydrate side chains
What is the purpose of opsonization?
The antibody promotes phagocytosis
The hypervarible region is a compontent of which fragment of the antibody?
Fab fragment
Only the heavy chain contributes to which fraction of the antibody?
Fc
Why does an antibody activate complement?
To enhance opsonization and lysis
The constant part of the heavy chain of IgM and IgG does what?
Fixes complement
Which isotype has an unclear function?
IgD
What is the main anitbody in a second response to an antigen?
IgG
When is IgM produced?
Primary response to an antigen
Which isotype induces the release of mediators from mast cells and basophils when exposed to an antigen?
IgE
Where is IgD found?
On the surface of many B cells and in serum
Which isotype fixes complement, crosses the placenta, opsonizes bacteria, and neutralizes bacterial toxins and viruses ?
IgG
Which isotype that guards the mucous membranes from attachement of bacteria and viruses?
IgA
IgE stimulates which type of hypersensitivity reaction?
Type I
IgE mediates immunity to what?
Worms
Which isotype fixes complement but does not cross the placenta?
IgM
Which isotype has the lowest concentration in the serum?
IgE
Which isotype found in secretions?
IgA
Which isotype crosses the placenta?
IgG
Which Ig epitope is common to a single class of Ig (5 classes, determined by the heavy chain)?
Isotype (IgG, IgA, IgM, IgE, IgD) Isotype=iso (same). Common to same class.
Which Ig epitope is determined by antigen-binding site?
Idiotype (specific for a given antigen) Idiotype=idio (unique). Hypervariable region is unique.
Which Ig epitope differs among members of the same species and can be on the light or heavy chain?
Allotype (polymorphism)
Antigen presenting cells have which type(s) of MHC protein?
MHC I and MHC II
Which class MHC proteins is the main determinants of organ rejection?
MHC II
How many class I genes does the MHC consist of?
3 (A, B, C)
What class of MHC antigen loading occurs in acidified endosomes?
MHC II
All nucleated cells have which type of MHC protein(s)?
MHC I
Which class MHC protein has 1 polypeptide with beta 2 microglobin?
MHC I
Where does MHC I antigen loading occur in the cell?
RER (viral antigens)
What are the 3 MHC II genes?
DP, DQ, DR
Which class MHC protein has 2 polypeptides and and alpha and beta chain?
MHC II