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78 Cards in this Set

  • Front
  • Back
deficiencies in complement
pyogenic infections- H influenza, strep pneumoniae, s. aureus
autoantibodies and immune complexes
otitis media, pneum, sinusitis
deficiency in cell mediated immunity
microorganism infection
fungus
X-LA
failure of B cell maturation
no B cells
IgA and IgG deficiency
differentiation of B cells fails
IgG2
recognizes capsule of virus
HIGM
deficient in IgA and IgG
problem is mutated CD40 on activated T cell
Common variable immunodeficiency
defects in T cell signalling to B cells
follows EBV
B cells not defective
transient hypogammaglobulinemia
B cells lack stimulus from TH cells
SCID
Thymus does not develop
diarrhea, pneum, yeast infections
infants die unless marrow transplant
causes of SCID
defective genes for IL2 receptore
genetic def. of ADA or PNP
MHC II deficiency
TH deficiency results
DiGeorge anomoly
defect in thymus embryogenesis

wide eyes, low ears, cardiac
hereditary AT
T cell deficiency, sinus lung infections
7 and 14- defect in DNA repair
Wilscott Aldrich syndrom
severe eczema
X linked
Def. in C1 C2 C4 C3, factor H and I
no clearance of IC
Hereditary angineurotic edema
C1 inhibitor def.
autosomal dominant
cyclophosphamide
alkylates DNA, no replication
affects B cells more thn T cells
not PMNs
management of autoantibody and allograft rejection
methotrexate
analog of folic acid
decreases Ig and PMNs
no affect on T cells
cyclosporin, tacrolimus, rapamycin
bind to imminuphilins
inhibit T cells, and anitgen resentation by L cells and monocytes
indernutrition
most common cause of immunodeficiency
vit B3 and folate
deficiency means reduced cell mediated immune response
Type 1
Through mucus- TH2 develops IgE by IL13 and IL4
hay fever
MMC in nose
asthma
MMC in bronchiole tissue
hyposensitization
muscular
TH1 develops IFNy so IgG and no TH2
tx for Type 1
corticosteroids- dec. mast cells
sodiom cromoglycate
cyclosporin A- inh. IL2 rec.
antihistamines
Type II
IgG and IgM
complement component C1
hemolytic disease of the newborn
large liver, spots on baby
Type III
persistent infection
autoimmune disease
inhalation of antigenic material
endothelial retraction, microthrombi Authus rxn
Type IV
cell mediated rather than humoral
1- contact 2- tuberculin (42-72)
3- granulomatous (21-28 days)
contact hypersensitivity
haptens bound to carriers sensitize-- memory CD4 cells
elicitation- release IFNy which activates keratinocytes
macrophages release PGs to down regulate
epithelioid cells
under chronic cytokine stim.
secreate lots of TNFa
types of granulomas
TB, leprosy, schistosomiasis, sarcoidosis, Crohn's disease
50% of colds
rhinoviruses and coronaviruses
adenoviruses can infect the pharynx and the eye giving...
pharyngoconjuctival fever
EBV infection of pharynx
petechiae on soft palate
pharyngitis bacteria
streptococcus pyognes- impt
corynebacterium diphtheriae
H inluenza- epiglotitis
compllication of S pyogenes
peritonsillar abcess
otitis media, sinusitis
scarlet fever- erythrogenic toxin
rheumatic fever
acute glomerulonephritis- IC
acute otitis media
caused by viruses
Strep pneumoniae & H. influenza
otitis externa
"swimmer's ear"
S aureus, candida albicans, proteus, Ps. aeruginosa
acute sinusitis
S pyogenes
laryngitis and tracheitis
parainfluenza viruses
also RSV and influenza
CROUP
bortedella pertussis toxins
pertussis toxin- signals
adenylate cyclase toxin- inh. chemotxis and phag.
tracheal cytotoxin
endotoxin
bronchiolitis
75% RSV
25% myc. pneumoniae
only in children
vaccine for premature babies
strep. pneumoniae
classic bact cause of community acquirred pneum.
major cause of death in developing countries
measles leading to pneumonia
Measles signs
Koplik's spots in mouth- results in otitis media and neum.
give Vit A for prevention
vaccine may induce autism
aspergillosis- many fungi in this genus
can form fungal ball in lungs, asthma pts react, gives disseminated disease in AIDS pts
CF
all pts at 15yrs have ps. aerunginosa
styes are caused by
S aureus
chlamydia trachomatis
D-K inclusion conj. an STD
A-C trachoma
other bact for conjunctivitis
step pneumoniae, H influenza, Leptospira
H aegyptius causes
pink eye
killed vaccine produce what type of response
humoral
and you have to get booster shots
capsule particle for strep vaccine requires boosters because it is Tind.
no Th activation so no memory cells
skin bacteria
staph epidermis, micrococcus, proprionibacterium, corynebacterium, candida
upper respiratory tract
staph. epidermis, S aureus, strep pneumoniae
lower resp. tract
NONE
strep. mutans
dental caries
healthy gingiva
gram positive
strept. sanguis, actinomyces
sick ginigiva
gram neg.
porphyromonas, prevetolla, bacteriodes, fusobacterium
large intestine
pos- E coli, bacteroids, fusobacterium
neg- lactobacillis, cl. perfringens
genitourinary tract
staph epidermis, strept faecalis, Neisseria, E coli sometimes
bortadella abortus
5' GMP that prevents degranulation of peroxidases from PMN
capsules
pneumococci and meningococci
streptokinase
activates plasmin
coagulase produced by
staphylococci
enterotoxins
cAMP- cholera, E coli, B, cereus
kill cells- Shigella, E coli
streptococci viridans
causes endocarditis
S aureus causes...
osteomyelitus
spread via CSF
mumps- invade
local- Neisseria meningitidis, H influenza, strep pneumoniae
shed continually-
EBV, Hep B
shed intermittently
HSV, polyoma, malaria, typhoid
S pyogenes tries to mimic but
Abs made to both it and self peptide
schistoma can coate themselves
avoid detection
infection of immune cells
T- HIV, measles
B- EBV
macrophage- HIV leishmania
dendritic- HIV
N gonorrhea, S pneum., H influenza cleave...
IgA
HSV produces gC that is a receptor for
C3b