Immunology 2: Lecture 1

Front 1

Define virus

Back 1

Intracellular obligate parasite

Front 2

Define the taxonomy of a virus

Back 2

Family, genus, species, strain/genotype

Front 3

Describe the taxonomy of Togaviridae

Back 3

Togaviridae (family)
Alphavirsus ( genus)
Ross river fever
Barmah forrest virus
chukungunya

Front 4

Descrie the taxonomy of Flaviviridae

Back 4

Flaviviridae (family)
Pestivirus (genus)
- Hepcvirus
- Hepatitis C
- Flavivirus
- Japanese encephalitis
- Murray river encephalitis
- Yellow fever
- Dengue

Front 5

Describe species of Flavivirus

Back 5

Front 6

What are the three types of DNA genome?

Back 6

Front 7

What are the three capsid structures of viruses?

Back 7

isohedral structure
helical
complex

Front 8

Give an example of a virus with isohedral symmetry

Back 8

isohedral structure which has 20 sides and has 2,3 and 5 fold symmetry
- herpes virus
- adenovirus

Front 9

Describe the helical capsid of a virus

Back 9

cylindrical structure with helix of proteins, which ahs nucleic acid inside of the protein helix.
Examples include: Rabies and bat lyssavirus

Front 10

Describe the capsid structure of a complex capsid and give an example

Back 10

contains two membranes, an inner and outer membrane. Outer membrane has membrane proteins with the inner membrane enveloping the nucleic acid. Example: Poxviridae

Front 11

What capsid structures can a DNA virus have?

Back 11

**

Front 12

What capsid structures can a RNA virus have?

Back 12

**

Front 13

Describe the Baltimore Classifcation

Back 13

- developed by David Balitmore
- Classifies viruses based on genome
- based on fact that all viruses need to produce mRNA to replicate

Front 14

Diagnosis of a recent infection

Back 14

1. Detection of agent compatible with disease symptoms
2. 4x increase in Ab titire in paired sera 7-10 days apart tested in parallel (to minimise error)
3. Detection of IgM Ab against an agent compatible with symptoms within 4-8 weeks of onset of symptoms.