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50 Cards in this Set
- Front
- Back
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CD2 (LFA2)
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Expressed on
T cells, NK cells Adhesion Molecule |
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CD3
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Expressed on
T cells, thymocytes Signal Tranductino by TCR |
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CD4
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Expressed on
TH Cells, Thymocytes, Monos, Macs Coreceptor for TCR-MHCII interaction Receptor for HIV |
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CD8
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Expressed on
CTL some Thymocytes Coreceptor for TCR-MHCI interaction |
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CD14
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Expressed on
NK, Macs, Neutro Binds LPS |
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CD16
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(Fc Receptor)
Expressed on NK, Macs, Neutros Opsonization, ADCC |
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CD18
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Expressed on
Leukocytes Cell Adhesion Molecule (Missing in Leukocyte adhesion deficiency) |
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CD19
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Expressed on
B Cells Coreceptor with CD21 for B cell activation (signal transduction) |
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CD20
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Expressed on
Most B cells Unknown B cell activation |
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CD21
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Expressed on
Mature B Cells Receptor for complement C3d Forms complex with CD19 Epstein-Barr Virus receptor |
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CD28
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Expressed on
T Cells T cell receptor for costimulatory molecule B7 |
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CD34
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Expressed on
Precursors of Hematopoietic cells, endo in HEV Cell-Cell adhesion Binds L-selectin |
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CD40
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Expressed on
B cells, Macs, Dend, Endo Binds CD40L T cell, B cell, Mac, Dendritic ,endothelial Activation |
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CD45
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Expressed on
Hematopoietic Cells Plays role in T- and B- cell antigen receptor mediated signaling |
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IL-1
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Secreted by
Monos, Macs, B cells, Dend, Endo Target TH Cells Costimulates activation B Cells Maturation Colonal expansion NK Cells Enhances activity Endo Cells Increase expression ICAMs Macs/Neutros Chemotactically attracts Hepatocytes Synthesis of acute phase proteins Hypothalamus Fever |
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IL-2
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Secreted by
TH cells Target Ag primed TH and CTLs Proliferation, Enhances act. |
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IL-3
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Secreted by
TH cells, NK Targets Myeloid Hematopoietic Growth Differentiation |
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IL-4
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Target
Ag primed B-cells Costim activation Activated B-Cells prolif/Diff/Induces class switching IgG and IgE |
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IL-5
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Secreted by
TH2 Targets Activated B-cells Prolif/Diff/Induces Class Switch to IgA |
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IL-6
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Secreted by
Monos, Macs, TH2, BM stromal cells Targets Prolif B cells- promotes diff into plasma cells Plasma cells- Stim Ab secretion Myeloid Stem- Promotes diff Hepatocytes- Induces syn of acute phase proteins |
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IL-7
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Secreted by
BM, Thymic Stromal Cells Target Lymphoid Stem Cell Induces diff into progenitor B and T Cells |
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IL-8
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Secreted by
Macs Endo Targets Neutrophils Chemokine, induces adherence to endo and promotes extravasation |
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IL-10
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Secreted by
TH2 Cells Targets Macs Suppresses cytokine production by TH1 Cells |
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IL-12
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Secreted by
Macs, B cells Targets Activated CD8+ cells Acts with IL-2 to induce diff into CTLs NK and LAK cells and TH1 Cells Stimulates Prolif |
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IFN a
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Secreted by
leukocytes Target Uninfected cells Inhibits Viral Replication |
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IFN b
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Secreted by
Fibroblasts Target Uninfected cells Inhibits Viral Replication |
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IFN g
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Secreted by
TH1, CTLs, NK Targets (Macs)- enhances activity (Many Cells)- Increase MHC 1&2 expression (Prolif B cell)- Induces class switching to IgG2a. Blocks Class Switch to IgE & Ig G1 (TH2 Cells )- Inhibits Prolif (Inflamm Cells)- Mediates effects important in DTH |
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TGF b
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Secreted by
Platelets, Macs, Lymphs, Mast Targets Prolif B cells Induces Class Switch to IgA |
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TNF a
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Secreted by
Macs, NK Target (Tumor Cells)- Cytotoxic effect (Inflamm Cells)- Induces cytokine secretion. Causes cachexia of chronic inflamm |
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TNF b
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Secreted by
TH1 and CTLs Target (Tumor cells)- Has cytotoxic effects (Macs and Neutros)- Enhances Phagocytosis |
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G-CSF
Granulocyte colony-stimulating factor |
Secreted by
Macs and TH Cells Target Bone Marrow Granulocyte precursors Induces prolif. used clinically to counteract neutropenia following chemotherapy |
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GM-CSF
Granulocyte Macrophage colony-stimulating factor |
Secreted by
Macs and TH Cells Target Bone Marrow Macrophage/granulocyte precursors Induces prolif. used clinically to counteract neutropenia following chemotherapy |
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Early Adhesion/Late(Strong) Adhesion
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Early- Selectin- Addressin
Late- Integrin- ICAM |
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Selectins
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Bind carbs, initiate leukocyte-endothelial interaction
All Bind Addressins L Selectin- Leukocytes P Selectin- Endothelium E Selectin- Activated Endothelium |
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Addressins
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Mucin-like vascular addressins (bind to L-selectin, Initiate leukocyte endothelial interaction)
CD34 - Endothelial Venules GlyCAM-1 - HEV MAdCAM - Mucosal Lymph Tissue Venules |
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Integrins
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Bind to cell-adhesion molecules & extracellular matrix. Strong.
Binds ICAMs LFA-1 -(ICAMs) Monos,T cell, Macs, Neutros, Dend CR3 - (ICAM-1, iC3b, Fibrinogen) Neutros, Monos, Macs CR4 - (iC3b) Dend, Macs, Neutros |
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Immunoglobulin Superfamily
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Role in cell adhesion. Ligand for integrins.
CD2 on (Tcells) binds LFA-3 ICAM-1 on (Act Vessels, Lymphocytes, Dend Cells) binds LFA-1 and CR3 ICAM-2 on Rest Vessels, Dend Cells) binds LFA-1 ICAM-3 on (Lymphocytes) binds LFA-1 LFA-3 on (Lymphocytes, APCs) binds CD2 VCAM-1 on (Act Endothelium) binds VLA-4 |
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Omenn Syndrome
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Missense in Rag genes (partial Rag activity)
Lack of Bcells Decrease in Tcells. Rash Failure to Thrive |
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SCID
Severe Combined Immuno Deficiency |
Null mutation in Rag.
No B or T cells. |
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LAD
Leukocyte Adhesion Difficiency |
Lack of CD18 = Common B2 chain of Integrins
No migration into sites of infection. Increase in granulocyes. No puss or abscess. |
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CGD
Chronic Granulomatous Disease |
Incomplete NADPH Oxidase Unit = No O*
Chronic Infections with Cat + organisms. Catalase breaks down H2O2. Myeloperoxidase uses H2O2--> ClO- No Respitory Burst (O* or ClO-) in Cat + |
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Super Ag
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Binds TCR (b domain) to MHCII (a chain)
Releases INFg (Colonal Expansion)--> TH1 Response --> Macs, IL-1, IL-6, TNFa Toxic Shock Syndrome (Strep pyrogenes, Staph aureus) Kawasaki Disease Eczema Guttate psoriasis Rheumatoid arthritis (Boriella) Diabetes mellitus Scarlet fever (Strep pyrogenes) |
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Hyper IgM Syndrome
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Lack of CD40L = Bcell activation not possible
No Isotype Switch--> No Ig G, A or E No Germinal Centers Increase in Respiratory Infections |
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MHC I Deficiency
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Failed TAP or Nonfunctional MHC = No CD8+ Cells
Susceptible to Viral Infections High Antibody Response (No Neg feedback from CD8) NK cells need to compensate |
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Chediak Higashi Syndrome
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Phagocytic Disease
Phagolysosome formation Fail. Bacteria survival Secretion of lytic secretory granules by cytotoxic T cells is also affected. |
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Glucose-6-phosphate Dehydrogenase Deficiency
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Phagocytic Disease
G6PD supplies NADPH with energy. No O* in phagosome |
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Myeloperoxidase Deficiency
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Phogocytic Disease
Myeloperoxidase converts H2O2 to ClO- (used in RB) |
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Bruton
X-Linked Hypogammaglobinema |
Do not generate mature B cells. NO antibodies!
mutation at Bruton's tyrosine kinase (Btk) gene --> No B cell development (at the pro-B to pre B cell stage) |
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Transient Hypogammaglobulinemia Infancy
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after birth, leading to a reduction in the level of IgG (sometimes IgA and IgM)
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Common Variable Hypogammaglobinema
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decrease in ab
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